Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mecamylamine hydrochloride
Drug ID BADD_D01357
Description A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Indications and Usage For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension
Marketing Status approved; investigational
ATC Code C02BB01
DrugBank ID DB00657
KEGG ID D00611
MeSH ID D008464
PubChem ID 13221
TTD Drug ID D0V8HA
NDC Product Code 65085-0075; 69413-558; 79739-7183; 55486-1563
UNII 4956DJR58O
Synonyms Mecamylamine
Chemical Information
Molecular Formula C11H22ClN
CAS Registry Number 826-39-1
SMILES CC1(C2CCC(C2)C1(C)NC)C.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001---
Chorea17.01.01.001---
Constipation07.02.02.001--
Dizziness postural02.11.04.008; 17.02.05.004; 24.06.02.008---
Dry mouth07.06.01.002--
Fatigue08.01.01.002--
Glossitis07.14.01.001---
Ileus07.13.01.001--
Libido decreased19.08.03.001; 21.03.02.005--
Mydriasis06.05.03.004; 17.02.11.003---
Nausea07.01.07.001--
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Paraesthesia17.02.06.005; 23.03.03.094--
Pulmonary fibrosis22.01.02.006--
Pulmonary oedema02.05.02.003; 22.01.03.003--
Respiratory disorder22.02.07.002---
Sedation17.02.04.005---
Seizure17.12.03.001--
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Tremor17.01.06.002--
Urinary retention20.02.02.011--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Mental disorder19.07.01.002---
Decreased appetite08.01.09.028; 14.03.01.005--
Erectile dysfunction19.08.04.001; 21.03.01.007--
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