Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lymecycline
Drug ID BADD_D01333
Description Lymecycline is a broad-spectrum second-generation tetracycline antibiotic used for the treatment of acne and other susceptible bacterial infections.[L13880,L13883] It has been proven a cost-effective alternative to treatment with [minocycline] with comparable safety and efficacy.[A203255] Lymecycline was initially discovered in 1961. It is marketed by Galderma and used in the UK as well as New Zealand in addition to other countries. Lymecycline is not marketed in the USA, however, equivalent drugs are available, such as minocycline and [tetracycline].[A19429,L13880]
Indications and Usage Lymecycline is used for the treatment of acne in addition to other susceptible infections; propionibacterium is often the cause of acne.[L13880] Some of the infections that can be treated with lymecycline include upper respiratory tract infections, urinary tract infections, bronchitis, chlamydial infections, and rickettsial infections.[L13883]
Marketing Status approved; investigational
ATC Code J01AA04
DrugBank ID DB00256
KEGG ID D06884
MeSH ID D008194
PubChem ID 54707177
TTD Drug ID D04VEJ
NDC Product Code Not Available
UNII 7D6EM3S13P
Synonyms Lymecycline | N-Lysinomethyltetracycline | N Lysinomethyltetracycline | Tetracyclinemethylene Lysine | Lysine, Tetracyclinemethylene | Tetracycline-L-Methylene Lysine | Lysine, Tetracycline-L-Methylene | Tetracycline L Methylene Lysine | Lymecycline Hydrochloride | Hydrochloride, Lymecycline
Chemical Information
Molecular Formula C29H38N4O10
CAS Registry Number 992-21-2
SMILES CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)NCNCCCCC(C(=O)O)N)N(C )C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Blindness06.02.10.003; 17.17.01.003---
Blood bilirubin increased13.03.04.018--
Diarrhoea07.02.01.001--
Diplopia06.02.06.002; 17.17.01.005---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dysphagia07.01.06.003--
Enterocolitis07.08.03.003--
Erythema multiforme10.01.03.015; 23.03.01.003--
Eye disorder06.08.03.001---
Fontanelle bulging17.02.05.006; 18.04.04.001---
Gastrointestinal disorder07.11.01.001---
Gastrointestinal pain07.01.05.005--
Glossitis07.14.01.001---
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatitis09.01.07.004---
Hypersensitivity10.01.03.003--
Immune system disorder10.02.01.001---
Intracranial pressure increased17.07.02.002---
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Nausea07.01.07.001--
Nervous system disorder17.02.10.001---
Neutropenia01.02.03.004---
Oesophageal ulcer07.04.05.002--
Oesophagitis07.08.05.001--
Pancreatitis07.18.01.001--
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