Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lurasidone
Drug ID BADD_D01330
Description Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.
Indications and Usage Treatment of schizophrenia.
Marketing Status approved; investigational
ATC Code N05AE05
DrugBank ID DB08815
KEGG ID D04820
MeSH ID D000069056
PubChem ID 213046
TTD Drug ID D01QGX
NDC Product Code 50370-0036
UNII 22IC88528T
Synonyms Lurasidone Hydrochloride | Hydrochloride, Lurasidone | Lurasidone HCl | HCl, Lurasidone | SM 13496 | 13496, SM | SM13496 | SM-13,496 | SM 13,496 | SM13,496 | SM-13496 | Lurasidone | N-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinylmethyl)-1-cyclohexylmethyl)-2,3-bicyclo(2.2.1)heptanedicarboximide | Latuda
Chemical Information
Molecular Formula C28H36N4O2S
CAS Registry Number 367514-87-2
SMILES C1CCC(C(C1)CN2CCN(CC2)C3=NSC4=CC=CC=C43)CN5C(=O)C6C7CCC(C7)C6C5=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Suicidal behaviour19.12.01.006---
Activation syndrome17.02.05.041; 19.06.02.0080.004230%-
Psychiatric decompensation19.01.02.0100.000984%-
Dementia with Lewy bodies17.03.01.004; 19.20.02.003---
Oromandibular dystonia17.01.03.0060.000721%-
Oropharyngeal pain07.05.05.004; 22.12.03.016--
Umbilical cord around neck18.04.14.0040.000492%-
Violence-related symptom19.05.01.0220.000492%-
Tachyphrenia17.03.03.007; 19.10.03.0100.001672%-
Excessive eye blinking06.05.01.004; 17.17.02.0100.000492%-
Attention deficit hyperactivity disorder19.21.04.0040.001672%-
Drug effect less than expected08.06.01.0360.001115%-
Drug effective for unapproved indication08.06.01.037; 12.09.02.0010.000492%-
Drug ineffective for unapproved indication08.06.01.038; 12.09.02.0020.003443%-
Hypoprolactinaemia05.03.02.0080.001115%-
Manic symptom19.16.02.0030.000721%-
Psychotic symptom19.03.01.0120.000492%-
Therapeutic product effect incomplete08.06.01.0520.002394%-
Therapeutic product effect increased08.06.01.0530.003345%-
Therapy partial responder08.06.01.0640.001115%-
Treatment noncompliance08.06.01.067; 12.09.02.0060.001869%-
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