Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Loxapine
Drug ID BADD_D01326
Description An antipsychotic agent used in schizophrenia. [PubChem]
Indications and Usage For the management of the manifestations of psychotic disorders such as schizophrenia
Marketing Status approved
ATC Code N05AH01
DrugBank ID DB00408
KEGG ID D02340
MeSH ID D008152
PubChem ID 3964
TTD Drug ID D0U5OE
NDC Product Code 51097-001; 0527-1395; 50090-4701; 70518-0347; 0591-0369; 35573-436; 35573-438; 35573-439; 70518-1792; 0591-0370; 62135-492; 64850-892; 0591-0372; 0591-0371; 0527-1397; 70518-0416; 64850-890; 0527-1394; 0527-1396; 53296-0095; 62135-493; 70518-1681; 64850-891; 64850-893; 70518-0346; 70518-1896; 35573-437
UNII LER583670J
Synonyms Loxapine | 2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine | Oxilapine | Cloxazepine | Loxapine Hydrochloride | Hydrochloride, Loxapine | Loxitane | Loxapine Succinate | Succinate, Loxapine | Loxapinsuccinate | Loxipine Succinate | Loxipine Maleate | Maleate, Loxipine | CL-71,563 | CL 71,563 | CL71,563 | Loxapine Monohydrochloride
Chemical Information
Molecular Formula C18H18ClN3O
CAS Registry Number 1977-10-2
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Therapeutic response decreased08.06.01.016---
Throat irritation07.05.05.037; 22.12.03.029---
Throat tightness19.01.02.005; 22.12.03.031---
Thrombocytopenia01.08.01.002---
Tremor17.01.06.002--
Urinary retention20.02.02.011--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Wheezing22.03.01.009--
Paraesthesia oral07.05.05.035; 17.02.06.008---
Angiopathy24.03.02.007---
Electrocardiogram change13.14.05.014---
Mediastinal disorder22.09.03.001---
Psychotic disorder19.03.01.002--
Pulmonary function test decreased13.19.01.001---
Liver injury09.01.07.022; 12.01.17.012---
Reduced facial expression17.01.05.016; 19.01.02.021---
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