Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Loratadine
Drug ID BADD_D01317
Description Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis.[A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.[A176441]
Indications and Usage Loratadine is a 2nd generation antihistamine and is used to manage symptoms of allergic rhinitis, wheal formation, urticaria, and other allergic dermatologic conditions.[A176435][A176438][L8486]
Marketing Status approved; investigational
ATC Code R06AX13
DrugBank ID DB00455
KEGG ID D00364
MeSH ID D017336
PubChem ID 3957
TTD Drug ID D06ABF
NDC Product Code 80070-110; 51927-4219; 59651-185; 63552-038; 65015-684; 11523-6655; 11523-7237; 11673-558; 21130-646; 36800-608; 36800-755; 37808-131; 41163-612; 41250-612; 41520-131; 43598-758; 49035-612; 49035-806; 51316-915; 53943-035; 55301-612; 56062-990; 57344-193; 58602-744; 58602-831; 59556-882; 59779-612; 0363-9937; 66715-6432; 67091-245; 67751-163; 68016-053; 68016-131; 68071-2801; 68071-2934; 68788-8349; 69230-328; 70000-0583; 70518-0135; 70518-1335; 70518-1399; 73581-203; 73581-230; 62331-018; 11523-7200; 11523-7202; 11822-0446; 11822-2022; 11822-8329; 41163-364; 46122-423; 49035-611; 50090-5506; 51316-503; 51660-106; 51660-526; 51672-2092; 55289-728; 55910-611; 55910-970; 56062-132; 57483-950; 59726-758; 60760-569; 62207-787; 0363-9994; 63941-131; 68016-167; 68071-2208; 68391-314; 68788-7291; 68998-414; 69452-211; 70518-2951; 70677-1053; 70985-017; 11014-0031; 62938-0005; 11523-0800; 11523-7157; 11673-115; 11673-612; 11822-0558; 11822-0919; 11822-3276; 21130-195; 21130-526; 21130-780; 21130-914; 21130-999; 0113-1019; 41250-629; 41250-890; 41520-716; 43598-756; 45802-650; 46122-539; 47682-203; 47682-403; 49035-953; 50090-4316; 50090-5067; 50090-5532; 50268-489; 51660-527; 51660-754; 54838-554; 55154-8082; 55681-303; 59726-915; 0363-2108; 0363-9150; 63941-193; 69168-414; 69230-317; 69230-322; 69842-085; 70000-0473; 55910-539; 55910-806; 59556-917; 62011-0248; 62011-0371; 0363-1612; 63548-0753; 0363-9603; 0363-9955; 63868-462; 0363-9995; 63868-669; 66715-6532; 67091-350; 68016-088; 68016-094; 68084-248; 69256-612; 0536-1367; 71335-0100; 0615-8217; 72983-500; 80070-120; 0904-6852; 59651-035; 11523-4328; 21130-301; 21130-452; 24385-543; 30142-017; 46122-550; 47682-913; 49348-818; 51672-2131; 51824-075; 53117-309; 55315-528; 58602-702; 58602-821; 58602-881; 61919-142; 63868-414; 63981-612; 67751-153; 68016-055; 68071-3412; 69842-686; 69842-894; 70000-0213; 82501-1580; 10888-8213; 61474-4268; 65015-803; 65691-0042; 66577-046; 11523-4329; 11523-4359; 11523-4364; 11673-986; 11673-996; 11822-0612; 0113-1191; 36800-853; 37205-378; 0113-9755; 41226-686; 41250-539; 43598-707; 51660-753; 55700-097; 57243-200; 60000-950; 63629-7772; 63868-151; 0378-8880; 67091-408; 68016-526; 68071-3414; 68210-4110; 69452-283; 69842-337; 69842-895; 70000-0125; 71335-1461; 72036-193; 72288-446; 72288-451; 72888-029; 10888-8212; 66577-012; 68554-0003; 11523-0007; 11523-4330; 11523-7333; 11822-9999; 16714-898; 30142-446; 0113-7671; 49035-061; 50090-1454; 51316-502; 51660-112; 51672-2085; 55154-4375; 56062-526; 57483-955; 58602-818; 58602-830; 58602-847; 59556-301; 62011-0348; 0363-0771; 0363-0858; 63187-100; 64024-023; 66715-9732; 68196-301; 68391-301; 68788-7653; 69842-242; 69842-540; 69842-953; 70264-030; 71309-007; 72983-501; 80159-103; 81522-612; 38779-2857; 51552-1210; 62993-0803; 63827-0001; 65015-802; 11523-1527; 11523-4331; 11523-7160; 11822-0620; 25000-021; 30142-723; 30142-984; 33992-0612; 0113-7612; 37808-506; 41520-612; 47682-912; 49738-686; 50090-6164; 50594-010; 52904-630; 54838-558; 55319-099; 55910-594; 59779-528; 0363-0752; 0363-0754; 63868-577; 68071-2971; 68998-309; 69168-309; 69848-019; 70000-0252; 70010-162; 70677-0029; 70677-0145; 71335-1651; 49452-4135; 11673-111; 11822-2131; 11822-7240; 16571-822; 30142-612; 0113-1719; 41250-716; 49035-538; 50090-0836; 53943-116; 53943-975; 56062-900; 62011-0305; 0363-0699; 0363-1686; 0363-2131; 0363-4020
UNII 7AJO3BO7QN
Synonyms Loratadine | 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester | Claritin | Sch-29851 | Sch 29851 | Sch29851 | Alavert | Clarium
Chemical Information
Molecular Formula C22H23ClN2O2
CAS Registry Number 79794-75-5
SMILES CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Headache17.14.01.0010.000869%
Hepatic function abnormal09.01.02.0010.000080%-
Hyperhidrosis08.01.03.028; 23.02.03.0040.000254%
Hyperkinesia17.01.02.008---
Hypersensitivity10.01.03.0030.000557%
Hypertension24.08.02.001--
Hyperthermia08.05.01.001; 12.05.01.0020.000032%-
Hypoaesthesia17.02.06.023; 23.03.03.0810.000119%-
Hypotension24.06.03.002--
Immune system disorder10.02.01.001---
Increased appetite08.01.09.027; 14.03.01.0030.000080%-
Injection site erythema08.02.03.001; 12.07.03.001; 23.03.06.0150.000164%-
Injection site pain08.02.03.010; 12.07.03.0110.000180%-
Injection site reaction08.02.03.014; 12.07.03.0150.000109%
Injection site urticaria08.02.03.029; 10.01.06.003; 12.07.03.029; 23.04.02.0030.000109%-
Insomnia17.15.03.002; 19.02.01.0020.000447%
Intentional self-injury12.01.08.036; 19.12.01.0020.000080%-
Irritability08.01.03.011; 19.04.02.013--
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.0300.000048%-
Lacrimation increased06.08.02.0040.000109%
Laryngeal oedema10.01.05.003; 22.04.02.001; 23.04.01.0050.000048%
Lethargy08.01.01.008; 17.02.04.003; 19.04.04.0040.000064%
Loss of consciousness17.02.04.0040.000209%-
Malaise08.01.01.0030.000373%
Menstruation delayed05.05.01.010; 21.01.02.003---
Middle insomnia17.15.03.003; 19.02.01.0030.000048%-
Migraine17.14.02.001; 24.03.05.0030.000064%-
Mood altered19.04.02.0070.000048%-
Mouth ulceration07.05.06.0040.000048%-
Myalgia15.05.02.0010.000142%
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