Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Lomitapide mesylate
Drug ID BADD_D01312
Description Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Indications and Usage Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Marketing Status approved; investigational
ATC Code C10AX12
DrugBank ID DB08827
KEGG ID D09638
MeSH ID C473731
PubChem ID 11274333
TTD Drug ID D0H8VY
NDC Product Code 76431-110; 76431-120; 11014-0361; 11014-0460; 11014-0360; 66039-923; 76431-130; 11014-0362; 11014-0461; 48957-0086; 76431-105; 11014-0359; 11014-0459; 70600-005
UNII X4S83CP54E
Synonyms BMS201038 | BMS-201038 | BMS 201038 | lomitapide | Juxtapid | AEGR 733 | AEGR733 | AEGR-733
Chemical Information
Molecular Formula C40H41F6N3O5S
CAS Registry Number 202914-84-9
SMILES CS(=O)(=O)O.C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6 =CC=CC=C64)C(=O)NCC(F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Alanine aminotransferase13.03.04.002---
Alanine aminotransferase increased13.03.04.005--
Angina pectoris02.02.02.002; 24.04.04.002--
Aspartate aminotransferase13.03.04.008---
Back pain15.03.04.005--
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Constipation07.02.02.001--
Defaecation urgency07.02.04.001---
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dyspepsia07.01.02.001--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Gastrooesophageal reflux disease07.02.02.003--
Gastroenteritis07.19.03.001; 11.01.07.004---
Headache17.14.01.001--
Hepatic steatosis09.01.07.003; 14.08.04.005---
Hepatotoxicity09.01.07.009; 12.03.01.008---
Influenza11.05.03.001; 22.07.02.001---
Laryngeal pain22.12.03.010--
Nasal congestion22.04.04.001--
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.001--
Palpitations02.11.04.012--
Pyrexia08.05.02.003--
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
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