Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomefloxacin hydrochloride
Drug ID BADD_D01310
Description Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Indications and Usage For the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: S.pneumoniae, H.influenzae, S.aureus, P.aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E.coli, and K.pneumoniae.
Marketing Status approved; investigational
ATC Code S01AE04; J01MA07
DrugBank ID DB00978
KEGG ID D00873
MeSH ID C053091
PubChem ID 68624
TTD Drug ID D02KOF
NDC Product Code Not Available
UNII 9VC7S3ZXXB
Synonyms lomefloxacin | lomenfloxacin | 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid | lomefloxacin hydrochloride | Maxaquin | Logiflox | Ocacin | Okacin | Okacyn | SC 4711 | SC-4711 | Décalogiflox | NY 198 | NY-198
Chemical Information
Molecular Formula C17H20ClF2N3O3
CAS Registry Number 98079-52-8
SMILES CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Protein total decreased13.09.01.004---
Prothrombin time prolonged13.01.02.012---
Pruritus23.03.12.001--
Pseudomembranous colitis07.19.01.003; 11.02.02.002---
Pulmonary embolism22.06.02.001; 24.01.06.001---
Pulmonary oedema02.05.02.003; 22.01.03.003--
Purpura01.01.04.003; 23.06.01.004; 24.07.06.005--
Rash23.03.13.001---
Renal failure20.01.03.005---
Respiratory depression17.02.05.047; 22.02.01.010---
Respiratory disorder22.02.07.002---
Rhinitis11.01.13.004; 22.07.03.006--
Seizure17.12.03.001--
Skin discolouration23.03.03.005---
Skin disorder23.03.03.007---
Skin exfoliation23.03.07.003---
Skin hyperpigmentation23.05.01.003--
Skin ulcer23.07.03.003; 24.04.03.007--
Somnolence17.02.04.006; 19.02.05.003--
Specific gravity urine abnormal13.13.02.010---
Sputum increased22.02.03.007---
Stevens-Johnson syndrome10.01.01.045; 11.07.01.005; 12.03.01.014; 23.03.01.007--
Stomatitis07.05.06.005--
Strangury20.02.02.017---
Stridor22.04.02.003--
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Tachycardia02.03.02.007---
Tendonitis12.01.07.007; 15.07.01.003---
Thinking abnormal17.02.05.023; 19.10.03.001---
Thirst08.01.09.021; 14.03.02.007---
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