Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomefloxacin
Drug ID BADD_D01309
Description Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Indications and Usage For the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: S.pneumoniae, H.influenzae, S.aureus, P.aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E.coli, and K.pneumoniae.
Marketing Status approved; investigational
ATC Code J01MA07; S01AE04
DrugBank ID DB00978
KEGG ID D02318
MeSH ID C053091
PubChem ID 3948
TTD Drug ID D02KOF
NDC Product Code Not Available
UNII L6BR2WJD8V
Synonyms lomefloxacin | lomenfloxacin | 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid | lomefloxacin hydrochloride | Maxaquin | Logiflox | Ocacin | Okacin | Okacyn | SC 4711 | SC-4711 | Décalogiflox | NY 198 | NY-198
Chemical Information
Molecular Formula C17H19F2N3O3
CAS Registry Number 98079-51-7
SMILES CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Phobia19.06.03.002---
Photophobia06.01.01.004; 17.17.02.006--
Photosensitivity reaction23.03.09.003--
Polyuria20.02.03.002---
Pruritus23.03.12.001--
Pseudomembranous colitis07.19.01.003; 11.02.02.002---
Pulmonary embolism22.06.02.001; 24.01.06.001---
Pulmonary oedema02.05.02.003; 22.01.03.003--
Purpura01.01.04.003; 23.06.01.004; 24.07.06.005--
Rash23.03.13.001---
Renal failure20.01.03.005---
Respiratory depression17.02.05.047; 22.02.01.010---
Rhinitis11.01.13.004; 22.07.03.006--
Seizure17.12.03.001--
Shock24.06.02.002---
Skin discolouration23.03.03.005---
Skin disorder23.03.03.007---
Skin exfoliation23.03.07.003---
Skin hyperpigmentation23.05.01.003--
Skin ulcer23.07.03.003; 24.04.03.007--
Somnolence17.02.04.006; 19.02.05.003--
Stevens-Johnson syndrome10.01.01.045; 11.07.01.005; 12.03.01.014; 23.03.01.007--
Stomatitis07.05.06.005--
Strangury20.02.02.017---
Stridor22.04.02.003--
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Tachycardia02.03.02.007---
Tendonitis12.01.07.007; 15.07.01.003---
Tension19.06.02.005---
Thinking abnormal17.02.05.023; 19.10.03.001---
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