| Drug Name |
Ketotifen |
| Drug ID |
BADD_D01234 |
| Description |
Ketotifen is a benzocycloheptathiophene derivative[A231204] with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and [azatadine].[A231204]
Ketotifen was first developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of anaphylaxis.[A231204] In the US, it is now used in an over-the-counter ophthalmic formulation for the treatment of itchy eyes associated with allergies,[L32278] and in Canada a prescription-only oral formulation is available and indicated as an add-on therapy for children with atopic asthma.[L32283] In addition, oral ketotifen is used in Mexico and across Europe for the treatment of various allergic symptoms and disorders,[A231204] including urticaria, mastocytosis, and food allergy. |
| Indications and Usage |
Administered orally, ketotifen is indicated as an add-on medication in the chronic treatment of mild atopic asthma in children.[L32283] It is also available as an over-the-counter ophthalmic solution which is indicated for the temporary prevention of itching of the eye due to allergic conjunctivitis.[L32278] |
| Marketing Status |
approved |
| ATC Code |
R06AX17; S01GX08 |
| DrugBank ID |
DB00920
|
| KEGG ID |
D08105
|
| MeSH ID |
D007665
|
| PubChem ID |
3827
|
| TTD Drug ID |
D0YG7M
|
| NDC Product Code |
Not Available |
| UNII |
X49220T18G
|
| Synonyms |
Ketotifen | Ketotiphene | Ketotiphen | 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)-cyclohepta(1,2-b)thiophen-10-one | Ketotifene | Zaditen | Ketotifen Fumarate | Fumarate, Ketotifen |
