Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ketoprofen
Drug ID BADD_D01231
Description Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Indications and Usage For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.
Marketing Status approved; vet_approved
ATC Code M01AE03; M02AA10
DrugBank ID DB01009
KEGG ID D00132
MeSH ID D007660
PubChem ID 3825
TTD Drug ID D0W9WF
NDC Product Code 51604-0011; 71574-122; 0276-0506; 43235-0010; 51927-0304; 76465-0001; 12660-0006; 38779-3039; 49452-3924; 51927-0231; 45865-485; 0276-0504; 51927-0025; 51927-0057; 68981-031; 63275-9996; 82348-102; 63187-018; 38779-0078; 0378-8200; 51552-0307; 51927-0299; 79572-019
UNII 90Y4QC304K
Synonyms Ketoprofen | Benzoylhydratropic Acid | 2-(3-Benzoylphenyl)propionic Acid | Profenid | Alrheumum | Orudis | 19,583 RP | RP, 19,583 | RP-19583 | RP 19583 | RP19583 | Alrheumat
Chemical Information
Molecular Formula C16H14O3
CAS Registry Number 22071-15-4
SMILES CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal disorder07.11.01.001---
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.0090.004481%-
Gastrointestinal pain07.01.05.005--
Gastrointestinal perforation07.04.04.001---
Generalised tonic-clonic seizure17.12.01.0020.006721%-
Glossodynia07.14.02.001---
Gynaecomastia05.05.02.003; 21.05.04.003--
Haemarthrosis12.04.03.001; 15.01.01.004; 24.07.01.0460.002240%-
Haematemesis07.12.02.002; 24.07.02.0110.008961%-
Haematochezia07.12.02.003; 24.07.02.0120.003361%-
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemolysis01.06.04.002--
Haemoptysis02.11.04.009; 22.02.03.004; 24.07.01.006---
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatic failure09.01.03.0020.003361%
Hepatic function abnormal09.01.02.001---
Hepatitis09.01.07.004---
Hepatitis acute09.01.07.0050.004481%-
Hepatitis cholestatic09.01.01.0020.002240%-
Hepatocellular injury09.01.07.0080.012322%-
Hyperaemia24.03.02.0020.004929%-
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.0030.021283%
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hypocoagulable state01.01.02.004---
Hypoglycaemia05.06.03.001; 14.06.03.0010.002240%
Hypokalaemia14.05.03.0020.004481%
Hyponatraemia14.05.04.0020.002240%
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ADReCS-Target
Drug Name ADR Term Target
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