Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ketoprofen
Drug ID BADD_D01231
Description Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Indications and Usage For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.
Marketing Status approved; vet_approved
ATC Code M01AE03; M02AA10
DrugBank ID DB01009
KEGG ID D00132
MeSH ID D007660
PubChem ID 3825
TTD Drug ID D0W9WF
NDC Product Code 51604-0011; 71574-122; 0276-0506; 43235-0010; 51927-0304; 76465-0001; 12660-0006; 38779-3039; 49452-3924; 51927-0231; 45865-485; 0276-0504; 51927-0025; 51927-0057; 68981-031; 63275-9996; 82348-102; 63187-018; 38779-0078; 0378-8200; 51552-0307; 51927-0299; 79572-019
UNII 90Y4QC304K
Synonyms Ketoprofen | Benzoylhydratropic Acid | 2-(3-Benzoylphenyl)propionic Acid | Profenid | Alrheumum | Orudis | 19,583 RP | RP, 19,583 | RP-19583 | RP 19583 | RP19583 | Alrheumat
Chemical Information
Molecular Formula C16H14O3
CAS Registry Number 22071-15-4
SMILES CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.0020.011202%
Abdominal pain upper07.01.05.0030.023524%
Acne23.02.01.0010.002240%-
Affective disorder19.04.04.001---
Agitation17.02.05.012; 19.06.02.001--
Agranulocytosis01.02.03.0010.002240%-
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.0030.002240%-
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.0010.015682%
Anaphylactic reaction10.01.07.001; 24.06.03.0060.015682%
Anaphylactic shock10.01.07.002; 24.06.02.0040.020163%-
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.0010.062730%-
Anuria20.01.03.0020.003361%-
Anxiety19.06.02.002--
Aphasia17.02.03.001; 19.21.01.0010.002240%
Aplastic anaemia01.03.03.002---
Arrhythmia02.03.02.001---
Arthritis15.01.01.0010.002240%
Asthenia08.01.01.001---
Asthma10.01.03.010; 22.03.01.002---
Autoimmune hepatitis09.01.07.019; 10.04.09.0010.002240%-
Back pain15.03.04.0050.005601%
Blood urea increased13.13.01.006---
Bradycardia02.03.02.0020.004481%-
Bronchospasm10.01.03.012; 22.03.01.0040.005601%
Burning sensation08.01.09.029; 17.02.06.0010.002240%-
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002---
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ADReCS-Target
Drug Name ADR Term Target
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