| Drug Name |
Ketoconazole |
| Drug ID |
BADD_D01230 |
| Description |
Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.[A181802,T116] Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981.[A188054] At this time it was considered a significant improvement over previous antifungals, [miconazole] and [clotrimazole], due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis.[A188054,A188057] These effects combined with waning efficacy led to its eventual replacement by triazole agents, [fluconazole], [itraconazole], [voriconazole], and [posaconazole]. Ketoconazole and its predecessor [clotrimazole] continue to be used in topical formulations. |
| Indications and Usage |
Ketoconazole is used in the treatment or prevention of fungal infections including blastomycosis, candidiasis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.[FDA Label] In Europe, it is also used in the treatment of endogenous Cushing's syndrome.[L7736] |
| Marketing Status |
approved; investigational |
| ATC Code |
D01AC08; G01AF11; H02CA03; J02AB02 |
| DrugBank ID |
DB01026
|
| KEGG ID |
D00351
|
| MeSH ID |
D007654
|
| PubChem ID |
3823
|
| TTD Drug ID |
D0B4IF
|
| NDC Product Code |
60524-000; 62991-1461; 63629-8677; 68788-8257; 51927-0065; 52286-0009; 35573-433; 43538-531; 50090-6142; 63629-8675; 63629-8819; 70518-0915; 72789-052; 53002-8151; 63629-8820; 71205-105; 68071-2902; 70518-3367; 71085-008; 72189-428; 58159-091; 50090-0720; 51672-1298; 53002-8150; 68071-2309; 59349-0001; 0093-3219; 45802-465; 50090-6069; 63629-8676; 63646-010; 70518-2831; 72189-180; 51407-279; 55505-192; 63187-774; 68788-7755; 49452-3913; 66478-0145; 16714-955; 43538-530; 45802-532; 66267-400; 71713-097; 38779-0279; 53069-0390; 0168-0099; 51672-4026; 64380-827; 68788-9903; 71335-1849; 65085-0028; 50090-5265; 51552-0627; 51927-3194; 68981-023; 55505-196; 60429-020 |
| UNII |
R9400W927I
|
| Synonyms |
Ketoconazole | R-41400 | R 41400 | R41400 | R41,400 | Nizoral |
