| Drug Name |
Isoproterenol hydrochloride |
| Drug ID |
BADD_D01207 |
| Description |
Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160]
Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising the heart rate and cardiac output, without vasoconstriction.[A233724,A233729] The US patent from 1943 states that this compound had a wider therapeutic index and a stronger action than [adrenaline].[L33204]
Isoprenaline was granted FDA approval on 19 February 1948.[L33155] |
| Indications and Usage |
Isoprenaline is indicated to treat mild or transient episodes of heart block not requiring electric shock or pacemakers, serious episodes of heart block and Adams-Stokes attacks not caused by ventricular tachycardia or fibrillation, and bronchospasm during anesthesia.[L33160] Isoprenaline is also indicated for cases of cardiac arrest until preferable treatments like electric shock and pacemakers are available.[L33160] Isoprenaline is also indicated as an adjunct therapy to fluid and electrolyte replacement therapy in hypovolemic shock, septic shock, hypoperfusion, congestive heart failure, and cardiogenic shock.[L33160] |
| Marketing Status |
approved; investigational |
| ATC Code |
R03AB02; R03CB01; C01CA02 |
| DrugBank ID |
DB01064
|
| KEGG ID |
D01390
|
| MeSH ID |
D007545
|
| PubChem ID |
5807
|
| TTD Drug ID |
D0I8FI
|
| NDC Product Code |
14789-011; 42571-330; 55150-317; 69097-522; 70121-1604; 0548-9502; 54879-039; 70121-1605; 50711-0011; 66064-1021; 69918-735; 14789-015; 23155-660; 55150-316; 23155-661; 49452-3850; 52221-112; 42571-294; 0548-9501; 14474-036; 42533-112; 59651-141; 69575-4011; 71963-001; 70860-306; 14593-921; 17337-0420; 69097-521; 69918-731 |
| UNII |
DIA2A74855
|
| Synonyms |
Isoproterenol | Isopropylarterenol | Isopropylnoradrenaline | Isopropylnorepinephrine | 4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol | Isopropyl Noradrenaline | Noradrenaline, Isopropyl | Isoprenaline | Isadrine | Isadrin | Isoproterenol Hydrochloride | Hydrochloride, Isoproterenol | Novodrin | Isuprel | Izadrin | Norisodrine | Euspiran | Isoproterenol Sulfate | Sulfate, Isoproterenol |
