ADReCS

Pharmaceutical Information

Drug Name	Iodixanol
Drug ID	BADD_D01178
Description	Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents.
Indications and Usage	Iodixanol is a contrast agent during coronary angiography.
Marketing Status	approved
ATC Code	V08AB09
DrugBank ID	DB01249
KEGG ID	D01474
MeSH ID	C044834
PubChem ID	3724
TTD Drug ID	D0Y4YG
NDC Product Code	71806-222; 65219-381; 0407-2223; 65219-383; 0407-2222; 57884-0029
UNII	HW8W27HTXX
Synonyms	iodixanol \| Visipaque \| Visipaque Unique Softpac \| iodixanol-320 \| contrast media 2-5410-3

Chemical Information

Molecular Formula	C35H44I6N6O15
CAS Registry Number	92339-11-2
SMILES	CC(=O)N(CC(CN(C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I)C(=O)C)O)C2=C(C(= C(C(=C2I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Blood creatinine increased	13.13.01.004	-	-
Blood pressure fluctuation	24.06.01.002	0.007113%		-
Blood urea increased	13.13.01.006	-	-	-
Body temperature increased	13.15.01.001	-	-	-
Bone disorder	15.02.04.004	-	-	-
Bradycardia	02.03.02.002	0.024897%		-
Bronchitis	11.01.09.001; 22.07.01.001	-	-
Bronchospasm	10.01.03.012; 22.03.01.004	0.046237%
Bundle branch block	02.03.01.009	-	-	-
Burning sensation	08.01.09.029; 17.02.06.001	0.017783%		-
Cardiac arrest	02.03.04.001	0.053350%
Cardiac failure	02.05.01.001	-	-
Cardio-respiratory arrest	02.03.04.002; 22.02.06.007	0.065443%		-
Cardiogenic shock	02.05.01.003; 24.06.02.006	0.017783%		-
Cerebral infarction	17.08.01.004; 24.04.06.002	0.017783%		-
Cerebrovascular disorder	17.08.02.002; 24.03.05.002	-	-	-
Cheilitis	07.05.01.001; 23.03.03.025	0.015649%
Chest discomfort	02.02.02.009; 08.01.08.019; 22.12.02.002	0.149381%		-
Chest pain	02.02.02.011; 08.01.08.002; 22.12.02.003	0.056196%		-
Chills	08.01.09.001; 15.05.03.016	0.133020%
Choking	22.12.03.003	-	-	-
Choking sensation	19.01.02.002; 22.12.03.004	0.007113%		-
Circulatory collapse	24.06.02.001	0.017783%		-
Coagulopathy	01.01.02.001	-	-	-
Cold sweat	08.01.03.024; 23.02.03.002	0.042680%		-
Colour blindness acquired	06.02.09.002	-	-	-
Coma	17.02.09.001	-	-	-
Compartment syndrome	15.05.05.005; 24.04.05.006	0.010670%		-
Conduction disorder	02.03.01.008	-	-
Confusional state	17.02.03.005; 19.13.01.001	-	-

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