Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Imatinib mesylate
Drug ID BADD_D01137
Description Imatinib is a small molecule kinase inhibitor used to treat certain types of cancer. It is currently marketed by Novartis as Gleevec (USA) or Glivec (Europe/Australia) as its mesylate salt, imatinib mesilate (INN). It is occasionally referred to as CGP57148B or STI571 (especially in older publications). It is used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. It is the first member of a new class of agents that act by inhibiting particular tyrosine kinase enzymes, instead of non-specifically inhibiting rapidly dividing cells.
Indications and Usage For the treatment of Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML), Ph+ acute lymphoblastic leukaemia, myelodysplastic/myeloproliferative diseases, aggressive systemic mastocytosis, hypereosinophilic syndrome and/or chronic eosinophilic leukemia (CEL), dermatofibrosarcoma protuberans, and malignant gastrointestinal stromal tumors (GIST).
Marketing Status approved
ATC Code L01EA01
DrugBank ID DB00619
KEGG ID D01441
MeSH ID D000068877
PubChem ID 123596
TTD Drug ID D0AZ3C
NDC Product Code 11722-052; 66499-0073; 71052-670; 73309-059; 0078-0649; 60505-2901; 64679-794; 68001-490; 72819-186; 67877-633; 67877-634; 68001-491; 0054-0248; 42385-720; 54893-0066; 59923-723; 67184-0533; 68382-244; 70771-1394; 72485-203; 60505-2900; 60687-192; 60687-203; 67184-0532; 0054-0249; 70771-1395; 59923-724; 82009-087; 55111-939; 65344-0020; 0078-0401; 59651-240; 0093-7629; 64679-793; 72606-556; 62756-875; 0093-7630; 0904-6901; 42385-316; 59651-610; 81955-0002; 47335-475; 72485-202; 0904-6621; 54893-0005; 47335-472; 68382-245; 72606-557; 72819-185; 82009-086; 59651-241
UNII 8A1O1M485B
Synonyms Imatinib Mesylate | Mesylate, Imatinib | Imatinib Methanesulfonate | Methanesulfonate, Imatinib | STI571 | STI-571 | STI 571 | Gleevec | Glivec | ST 1571 | ST1571 | CGP 57148 | CGP57148B | CGP-57148 | CGP57148 | Imatinib | Alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide
Chemical Information
Molecular Formula C30H35N7O4S
CAS Registry Number 220127-57-1
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)( =O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Onychoclasis23.02.05.005---
Brain oedema12.01.10.010; 17.07.02.003--
Tumour haemorrhage16.32.03.008; 24.07.01.028--
Scleral haemorrhage06.07.01.002; 24.07.05.009---
Contusion12.01.06.001; 15.03.05.007; 23.03.11.002; 24.07.06.001--
Eye oedema06.08.03.013---
Thoracic operation25.13.05.001---
Musculoskeletal stiffness15.03.05.027---
Growth retardation05.03.02.007; 14.03.02.031; 15.03.05.016--
Tumour necrosis16.32.03.009; 24.04.02.013---
Transaminases increased13.03.04.036---
Haemorrhage24.07.01.002---
Restless legs syndrome15.05.03.012; 17.02.07.008---
Gastrointestinal toxicity07.08.03.006; 12.03.01.019---
Skin toxicity12.03.01.020; 23.03.03.032---
Blood alkaline phosphatase increased13.04.02.004--
Haemorrhagic ovarian cyst16.04.03.003; 21.11.01.007; 24.07.03.014---
Hepatic enzyme increased13.03.04.028---
Embolism24.01.01.009--
Mediastinal disorder22.09.03.001---
Decreased appetite08.01.09.028; 14.03.01.005--
Erectile dysfunction19.08.04.001; 21.03.01.007--
Lichenoid keratosis23.01.01.004---
Exfoliative rash23.03.07.006---
Bone marrow failure01.03.03.005--
Pharyngeal inflammation22.04.05.008--
Acute kidney injury20.01.03.016--
Central nervous system haemorrhage17.08.01.035; 24.07.04.016---
Heavy menstrual bleeding21.01.03.005---
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