Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Icodextrin
Drug ID BADD_D01124
Description Icodextrin is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stage renal disease. It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport via peritoneal lymphatic pathways.
Indications and Usage Used for continuous ambulatory peritoneal dialysis (CAPD) of diabetic patients or automated peritoneal dialysis (APD) for the management of end-stage renal disease.
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB00702
KEGG ID D03266
MeSH ID D000077607
PubChem ID 3517
TTD Drug ID D02YCH
NDC Product Code 66127-100
UNII 2NX48Z0A9G
Synonyms Icodextrin | Extraneal | Icodial
Chemical Information
Molecular Formula C8H8Cl2N4
CAS Registry Number 5051-62-7
SMILES C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin ulcer23.07.03.003; 24.04.03.007--
Swelling face08.01.03.100; 10.01.05.018; 23.04.01.018---
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Tachycardia02.03.02.007---
Tension19.06.02.005---
Thinking abnormal17.02.05.023; 19.10.03.001---
Thrombocytopenia01.08.01.002---
Tinnitus04.04.01.002; 17.04.07.004--
Toxic epidermal necrolysis10.01.01.006; 11.07.01.006; 12.03.01.015; 23.03.01.008--
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urticaria10.01.06.001; 23.04.02.001--
Vasculitis10.02.02.006; 24.12.04.027--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Onychomadesis23.02.05.006--
Balance disorder08.01.03.081; 17.02.02.007---
Fluid imbalance14.05.01.003---
Infusion related reaction08.01.03.002; 10.01.01.017; 12.02.05.009--
Catheter site erythema08.02.02.003; 12.07.02.003; 23.03.06.014---
Catheter site inflammation08.02.02.010; 12.07.02.010---
Lymphatic disorder01.09.01.003---
Musculoskeletal discomfort15.03.04.001---
Infusion site pain08.02.05.014; 12.07.05.002---
Hypertensive nephropathy20.01.08.004; 24.08.05.003---
Haemorrhage24.07.01.002---
Catheter site infection08.02.02.006; 11.01.08.022; 12.07.02.006---
Toxic skin eruption10.01.01.008; 12.03.01.073; 23.03.05.003---
Breast disorder21.05.04.004---
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