Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ibutilide fumarate
Drug ID BADD_D01122
Description Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR).
Indications and Usage Indicated for the rapid conversion of atrial fibrillation or atrial flutter of recent onset to sinus rhythm.
Marketing Status approved
ATC Code C01BD05
DrugBank ID DB00308
KEGG ID D00648
MeSH ID C067192
PubChem ID 5281065
TTD Drug ID D02MLW
NDC Product Code 0009-3794; 67457-366; 14474-040
UNII 9L5X4M5L6I
Synonyms ibutilide | N-(4-(4-(ethylheptylamino)-1-hydroxybutyl)phenyl)methanesulfonamide | U-82209E | U82209E | Corvert | ibutilide, fumarate salt (2:1), (+-)-isomer | U-70226E | ibutilide, (+)-isomer | ibutilide, (+-)-isomer | ibutilide, (-)-isomer | ibutilide, fumarate salt (2:1), (+)-isomer | U-82208E | U82208E | ibutilide fumarate
Chemical Information
Molecular Formula C44H76N4O10S2
CAS Registry Number 122647-32-9
SMILES CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O) (=O)C)O.C(=CC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Atrioventricular block02.03.01.002---
Bradycardia02.03.02.002---
Bundle branch block02.03.01.009---
Cardiac failure congestive02.05.01.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Electrocardiogram QT prolonged13.14.05.004--
Headache17.14.01.001--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Loss of consciousness17.02.04.004---
Nausea07.01.07.001--
Nodal arrhythmia02.03.03.020---
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Palpitations02.11.04.012--
Renal failure20.01.03.005---
Rhythm idioventricular02.03.04.019---
Shock24.06.02.002---
Sinus bradycardia02.03.03.009--
Sinus tachycardia02.03.03.010--
Supraventricular extrasystoles02.03.03.011---
Supraventricular tachycardia02.03.03.012--
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Tachycardia02.03.02.007---
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007---
Ventricular tachycardia02.03.04.010--
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