Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ibandronic acid
Drug ID BADD_D01117
Description Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss in dogs.[A203138] Ibandronate was granted FDA approval on 16 May 2003.[L13805]
Indications and Usage For the treatment and prevention of osteoporosis in postmenopausal women.[L13805,L13808]
Marketing Status approved; investigational
ATC Code M05BA06
DrugBank ID DB00710
KEGG ID D08056
MeSH ID D000077557
PubChem ID 60852
TTD Drug ID D08SJZ
NDC Product Code Not Available
UNII UMD7G2653W
Synonyms Ibandronic Acid | Ibandronate | 1-Hydroxy-3-(methylpentylamino)propylidenebisphosphonate | (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonate | Ibandronate Sodium Anhydrous | Boniva | Bonviva | Ibandronate Sodium | Ibandronic Acid, Sodium Salt, Monohydrate | RPR 102289A | RPR-102289A | RPR102289A | Bondronat | BM 21.0955 | BM 210955 | BM-21.0955 | BM21.0955 | BM-210955 | BM210955
Chemical Information
Molecular Formula C9H23NO7P2
CAS Registry Number 114084-78-5
SMILES CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.009249%-
Abdominal pain07.01.05.0020.007254%
Abdominal pain upper07.01.05.0030.009028%
Administration site reaction08.02.04.011; 12.07.04.0110.001077%-
Alopecia23.02.02.0010.004625%
Amnesia17.03.02.001; 19.20.01.001--
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000634%
Anaphylactic shock10.01.07.002; 24.06.02.004---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Anxiety19.06.02.002--
Arthralgia15.01.02.0010.042350%
Arthritis15.01.01.0010.001552%
Arthropathy15.01.01.003---
Asthenia08.01.01.001---
Asthma10.01.03.010; 22.03.01.002---
Azotaemia20.01.01.001---
Back pain15.03.04.0050.021128%
Benign neoplasm of skin16.26.01.006; 23.10.01.006---
Bladder pain20.02.02.001---
Blood calcium decreased13.11.01.002---
Blood creatinine increased13.13.01.004--
Blood parathyroid hormone increased13.10.07.002---
Body temperature decreased13.15.01.010---
Body temperature increased13.15.01.001---
Bone disorder15.02.04.0040.001172%-
Bone pain15.02.01.0010.042350%
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Bundle branch block02.03.01.009---
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