| Drug Name |
Hydroxyzine hydrochloride |
| Drug ID |
BADD_D01112 |
| Description |
Hydroxyzine is a first-generation histamine H1-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955,[A189726] and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus.[L9677] The active metabolite of hydroxyzine, [cetirizine], is also available as an active ingredient in allergic medications, and is responsible for much of its hydroxyzine's antihistaminic effect.[A189753] Hydroxyzine is also used for generalized anxiety disorder, tension caused by psychoneurosis, and other conditions with manifestations of anxiety.[L9677] |
| Indications and Usage |
Hydroxyzine is indicated for the symptomatic relief of anxiety and tension associated with psychoneuroses, and as an adjunct in organic disease states in which anxiety is manifested.[L9677] It is also indicated in the treatment of histamine-mediated pruritus and pruritus due to allergic conditions such as chronic urticaria.[L9677]
Canadian labeling states that hydroxyzine is also indicated in adults and children as a premedication prior to medical procedures, such as dental surgery.[L9680] It is also used in the control of nausea and vomiting, excluding nausea and vomiting of pregnancy.[L9680] |
| Marketing Status |
approved |
| ATC Code |
N05BB01 |
| DrugBank ID |
DB00557
|
| KEGG ID |
D00672
|
| MeSH ID |
D006919
|
| PubChem ID |
71612
|
| TTD Drug ID |
D0O6SX
|
| NDC Product Code |
0904-6618; 51927-0272; 57451-1184; 10702-010; 16714-082; 17856-0507; 31722-500; 50090-5297; 50090-6293; 59651-501; 63187-733; 63629-8740; 70518-1265; 71205-332; 71205-541; 71610-686; 72162-1333; 16714-083; 31722-501; 55700-760; 59651-499; 62135-545; 63739-486; 68071-2864; 68071-5286; 68788-7676; 71335-0961; 71335-2185; 72162-1332; 0904-0359; 65319-1096; 0093-5060; 42806-159; 43063-519; 51655-080; 51655-119; 60687-675; 63629-8738; 68071-3450; 70518-0425; 70518-1730; 70518-2279; 71205-155; 55154-7994; 59651-500; 62135-573; 63187-494; 67296-1532; 70518-2066; 72789-216; 0904-0358; 51604-0003; 10702-011; 69237-005; 70159-008; 61919-743; 70518-1832; 70518-2159; 70518-3574; 70934-981; 71335-0268; 0615-8082; 72789-271; 62991-2035; 16714-081; 31722-502; 42806-161; 43063-518; 50090-6395; 54838-502; 62135-574; 63187-354; 70518-2807; 66022-0303; 23155-500; 51655-467; 60687-664; 60687-686; 63629-4929; 68071-2229; 68071-2237; 68788-7854; 0517-4201; 71205-273; 71335-0246; 71335-1047; 72789-269; 38779-0298; 49452-3652; 23155-501; 62135-546; 0404-9877; 71205-083; 0093-5062; 23155-502; 43063-627; 60760-285; 62135-502; 62135-575; 63629-1856; 63739-483; 0517-5601; 72189-333; 13746-103; 10702-012; 43063-779; 43063-943; 43063-960; 43063-962; 51655-589; 62135-547; 0517-5602; 70518-0487; 71335-0935; 71335-1121; 0904-6617; 58793-007; 66022-0104; 0093-5061; 42806-160; 43063-963; 51655-076 |
| UNII |
CA67JF5Q4W
|
| Synonyms |
Hydroxyzine | 2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol | Hydroxyzine Dihydrochloride | Vistaril | Hydroxyzine Pamoate | Pamoate, Hydroxyzine | Orgatrax | Durrax | Atarax | Hydroxyzine Hydrochloride |
