Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Hydroxyurea
Drug ID BADD_D01110
Description An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Indications and Usage For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Marketing Status approved
ATC Code L01XX05
DrugBank ID DB01005
KEGG ID D00341
MeSH ID D006918
PubChem ID 3657
TTD Drug ID D07CWD
NDC Product Code 0904-6939; 35369-0006; 49452-3650; 55154-7143; 61269-403; 68084-284; 70518-3615; 51927-0072; 0555-0882; 55154-3554; 69315-164; 38779-1354; 42291-321; 71770-105; 49884-724; 17337-0023; 0003-6335; 0003-6337; 60429-265; 61269-835; 70518-0916; 55512-0003; 61269-402; 71770-120; 0003-0830; 51552-0851; 62049-135; 0003-6336; 61269-404; 10135-702; 71052-323; 17337-0022
UNII X6Q56QN5QC
Synonyms Hydroxyurea | Hydroxycarbamid | Oncocarbide | Hydrea
Chemical Information
Molecular Formula CH4N2O2
CAS Registry Number 127-07-1
SMILES C(=O)(N)NO
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pancreatic carcinoma07.21.09.002; 16.13.10.0010.000280%-
Pancreatitis07.18.01.0010.000168%
Pancreatitis acute07.18.01.0020.000280%-
Pancytopenia01.03.03.0030.001063%-
Panniculitis10.01.03.024; 23.07.02.0020.000112%-
Papule23.03.03.038---
Pemphigoid10.04.02.002; 23.03.01.0040.000112%-
Pericarditis02.06.02.0010.000168%
Peripheral sensory neuropathy17.09.03.0050.000168%
Petechiae01.01.03.002; 23.06.01.003; 24.07.06.0040.000224%-
Plasma cell myeloma01.14.02.004; 16.23.02.0040.000448%-
Platelet count decreased13.01.04.001--
Platelet disorder01.08.03.0010.000224%-
Pleural effusion22.05.02.0020.000504%
Pneumonitis22.01.01.0060.000280%
Polycythaemia01.07.01.0010.000168%-
Polycythaemia vera01.13.03.002; 16.21.03.0030.000336%-
Portal hypertension09.01.06.006; 24.08.06.0010.000112%
Portal vein thrombosis09.01.06.007; 24.01.03.0030.000112%
Pregnancy18.08.02.0040.000437%-
Premature baby18.04.02.0010.000660%-
Premature delivery18.07.01.0060.000660%
Premature rupture of membranes18.07.01.0030.000168%-
Prostatic disorder21.04.01.0010.000112%-
Pulmonary fibrosis22.01.02.0060.000112%
Pulmonary haemorrhage22.12.01.009; 24.07.01.0160.000112%
Pulmonary hypertension22.06.01.001; 24.08.03.0020.000336%
Pulmonary oedema02.05.02.003; 22.01.03.003--
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ADReCS-Target
Drug Name ADR Term Target
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