Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Guanfacine hydrochloride
Drug ID BADD_D01047
Description Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension[L11274] but is now indicated as an extended release tablet for the treatment of ADHD.[L11277] Guanfacine was first described in the literature in 1974.[A189841] Guanfacine was granted FDA approval on 27 October 1986.[L11274]
Indications and Usage Guanfacine is indicated alone or as an adjunct with stimulants to treat ADHD.[L11277]
Marketing Status approved; investigational
ATC Code C02AC02
DrugBank ID DB01018
KEGG ID D00606
MeSH ID D016316
PubChem ID 71401
TTD Drug ID D0WD8M
NDC Product Code 46016-2911; 63552-021; 65372-1177; 70518-3516; 46016-2912; 53747-096; 53069-0080; 63190-0250; 53296-0024; 63552-023; 63552-022; 60687-710; 42291-310; 63552-024; 68071-2719; 29300-458; 29300-459
UNII PML56A160O
Synonyms Guanfacine | Tenex | Guanfacine Hydrochloride | Hydrochloride, Guanfacine | Guanfacine Monohydrochloride | Monohydrochloride, Guanfacine | Lon798 | BS-100-141 | BS 100 141 | BS100141 | Estulic
Chemical Information
Molecular Formula C9H10Cl3N3O
CAS Registry Number 29110-48-3
SMILES C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agitation17.02.05.012; 19.06.02.001--
Alopecia23.02.02.001--
Amnesia17.03.02.001; 19.20.01.001--
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Asthenia08.01.01.001---
Atrioventricular block02.03.01.002---
Bradycardia02.03.02.002---
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Confusional state17.02.03.005; 19.13.01.001--
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Depression19.15.01.001--
Dermatitis23.03.04.002---
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dry mouth07.06.01.002--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dyspnoea02.11.05.003; 22.02.01.004--
Fatigue08.01.01.002--
Headache17.14.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypokinesia17.01.02.009---
Insomnia17.15.03.002; 19.02.01.002--
Iritis06.04.03.002; 10.02.01.022---
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