Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Granisetron
Drug ID BADD_D01040
Description A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Indications and Usage For the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy (including high dose cisplatin), postoperation, and radiation (including total body irradiation and daily fractionated abdominal radiation).
Marketing Status approved; investigational
ATC Code A04AA02
DrugBank ID DB00889
KEGG ID D04370
MeSH ID D017829
PubChem ID 5284566
TTD Drug ID D0J5KF
NDC Product Code 14778-0202; 47426-101; 63850-7308; 42747-726; 53104-7609; 55111-841; 55718-117; 54871-1091
UNII WZG3J2MCOL
Synonyms Granisetron | 1-Methyl-N-(endo-9-Methyl-9-Azabicyclo(3.3.1)non-3-yl)-1H-Indazole-3-Carboxamide | Kytril | BRL-43694A | BRL 43694A | BRL43694A | BRL-43694 | BRL 43694 | BRL43694 | Granisetron Hydrochloride | Hydrochloride, Granisetron | Granisetron Monohydrochloride | Monohydrochloride, Granisetron
Chemical Information
Molecular Formula C18H24N4O
CAS Registry Number 109889-09-0
SMILES CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tremor17.01.06.002--
Urinary incontinence17.05.01.008; 20.02.02.010--
Urinary tract infection11.01.14.004; 20.08.02.001--
Urticaria10.01.06.001; 23.04.02.001--
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007---
Vertigo04.04.01.003; 17.02.12.002--
Visual impairment06.02.10.013---
Vomiting07.01.07.0030.062377%
Application site vesicles08.02.01.009; 12.07.01.009; 23.03.01.0090.014045%-
Application site dryness08.02.01.011; 12.07.01.011; 23.03.03.0240.010534%-
Musculoskeletal discomfort15.03.04.001---
Application site swelling08.02.01.027; 12.07.01.0270.010534%-
Application site discolouration08.02.01.030; 12.07.01.030; 23.03.03.0230.024579%-
Angiopathy24.03.02.007---
Hepatic enzyme increased13.03.04.028---
Connective tissue disorder10.04.04.026; 15.06.01.006---
Malnutrition14.03.02.004---
Decreased appetite08.01.09.028; 14.03.01.005--
Ill-defined disorder08.01.03.0490.007023%-
Inner ear disorder04.04.02.002---
Hepatobiliary disease09.01.08.003---
Increased bronchial secretion22.12.01.002---
Skin haemorrhage23.06.07.001; 24.07.01.1030.007023%-
Application site burn08.02.01.038; 12.07.01.038; 23.03.11.0130.017556%-
Puncture site pain08.02.04.001; 12.07.04.002---
Liver injury09.01.07.022; 12.01.17.012---
Injury associated with device08.07.01.012; 12.01.08.0350.010534%-
Depersonalisation/derealisation disorder19.14.01.004---
Application site mass08.02.01.053; 12.07.01.0530.007023%-
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ADReCS-Target
Drug Name ADR Term Target
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