Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gatifloxacin
Drug ID BADD_D01006
Description Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan.
Indications and Usage For the treatment of bronchitis, sinusitis, community-acquired pneumonia, and skin infections (abscesses, wounds) caused by S. pneumoniae, H. influenzae, S. aureus, M. pneumoniae, C. pneumoniae, L. pneumophila, S. pyogenes
Marketing Status approved; investigational
ATC Code J01MA16; S01AE06
DrugBank ID DB01044
KEGG ID D00589; D08011
MeSH ID D000077734
PubChem ID 5379
TTD Drug ID D03CQE
NDC Product Code 53476-1155; 50383-189; 68180-435; 60758-615; 61314-672; 0023-3615
UNII L4618BD7KJ
Synonyms Gatifloxacin | 1-cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid | Gatifloxacine | Tequin | AM 1155 | AM-1155 | CG 5501 | BMS-206584 | BMS 206584 | BMS206584 | Zymar
Chemical Information
Molecular Formula C19H22FN3O4
CAS Registry Number 112811-59-3
SMILES CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypoglycaemia05.06.03.001; 14.06.03.001--
Hypoglycaemic coma05.06.03.004; 14.06.03.004; 17.02.09.005---
Hypotension24.06.03.002--
Infection11.01.08.002---
Injection site reaction08.02.03.014; 12.07.03.015--
Insomnia17.15.03.002; 19.02.01.002--
Instillation site pain08.02.01.008; 12.07.01.0080.001437%-
Iritis06.04.03.002; 10.02.01.022---
Keratitis06.04.02.002--
Lacrimation increased06.08.02.004--
Loss of consciousness17.02.04.004---
Lymphadenopathy01.09.01.002---
Macular oedema06.04.06.005---
Mental disability26.01.01.001---
Migraine17.14.02.001; 24.03.05.003---
Mouth ulceration07.05.06.004---
Muscle spasms15.05.03.004--
Muscular weakness15.05.06.001; 17.05.03.005--
Myalgia15.05.02.001--
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.001--
Neck pain15.03.04.009--
Nervousness19.06.02.003---
Neutropenia01.02.03.004---
Ocular hyperaemia06.04.05.004---
Oedema08.01.07.006; 14.05.06.010---
Oedema mouth07.05.04.001; 10.01.05.006; 23.04.01.008---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Oral candidiasis07.05.07.001; 11.03.03.004---
Palpitations02.11.04.012--
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ADReCS-Target
Drug Name ADR Term Target
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