Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gadodiamide hydrate
Drug ID BADD_D00986
Description Gadodiamide is a paramagnetic gadolinium-based contrast agent (GBCA) that is used in MR imaging procedures to assist in the visualization of blood vessels. It is intravenously injected and is commonly marketed under the trade name Omniscan.
Indications and Usage For intravenous use in MRI to visualize lesions with abnormal vascularity (or those thought to cause abnormalities in the blood-brain barrier) in the brain (intracranial lesions), spine, and associated tissues.
Marketing Status approved; investigational
ATC Code V08CA03
DrugBank ID DB00225
KEGG ID D01645
MeSH ID C064925
PubChem ID 153921
TTD Drug ID D03EEH
NDC Product Code 0407-0691; 0407-0690; 71806-069
UNII 0RPE15QPL0
Synonyms gadodiamide | Gd-DTPA bis-(methylamide) | Gd-DTPA-BMA | Omniscan | Omniscan Unique Softpack
Chemical Information
Molecular Formula C16H26GdN5O8
CAS Registry Number 131410-48-5
SMILES CNC(=O)CN(CCN(CCN(CC(=O)NC)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Gd+3]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash23.03.13.001---
Rash erythematous23.03.13.029---
Renal failure20.01.03.005---
Rhinitis11.01.13.004; 22.07.03.006--
Seizure17.12.03.001--
Shock24.06.02.002---
Somnolence17.02.04.006; 19.02.05.003--
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Tachycardia02.03.02.007---
Throat irritation07.05.05.037; 22.12.03.029---
Tinnitus04.04.01.002; 17.04.07.004--
Tremor17.01.06.002--
Urethral disorder20.07.01.002---
Urinary tract disorder20.08.01.001---
Urticaria10.01.06.001; 23.04.02.001--
Visual impairment06.02.10.013---
Vomiting07.01.07.003--
Acute coronary syndrome02.02.02.015; 24.04.04.011---
Musculoskeletal discomfort15.03.04.001---
Vasodilation procedure25.03.01.001---
Hepatic enzyme increased13.03.04.028---
Hot flush08.01.03.027; 21.02.02.001; 24.03.01.005--
Ill-defined disorder08.01.03.049---
Autonomic neuropathy17.05.01.009---
Renal impairment20.01.03.010---
Nephrogenic systemic fibrosis10.04.02.007; 15.06.01.009; 20.01.01.004; 23.03.02.012---
Acute kidney injury20.01.03.016--
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