Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gadobenate dimeglumine
Drug ID BADD_D00983
Description Gadobenic acid (in the form of gadobenate dimeglumine) is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for visualizing the CNS and heart. In contrast to conventional extracellular fluid contrast agents, gadobenate dimeglumine is characterized by a weak and transient binding capacity to serum proteins. This binding leads to an increased relaxivity of gadobenate dimeglumine and, consequently, to a considerably increased signal intensity over that of other agents.
Indications and Usage Gadobenate Dimeglumine is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for MRI of the heart, as well as and central nervous system in adults to visualize lesions with abnormal brain vascularity or abnormalities in the blood brain barrier, the brain, spine, or other associated tissues.
Marketing Status approved; investigational
ATC Code V08CA08
DrugBank ID DB00743
KEGG ID D04283
MeSH ID C064572
PubChem ID 105125
TTD Drug ID D01OIL
NDC Product Code 57876-333; 0270-5164; 0270-5264
UNII 3Q6PPC19PO
Synonyms gadobenic acid | 3,6,9-triaza-12-oxa-3,6,9-tricarboxymethylene-10-carboxy-13-phenyltridecanoic acid, gadolinium | Gd-BOPTA | gadobenic acid, dimeglumine salt | gadobenate dimeglumine | gadolinium-BOPTA-Dimeg | MultiHance | Gd(BOPTA)2 | B 19036 | B-19036 | gadolinium-benzyloxypropionyl tetraacetate
Chemical Information
Molecular Formula C22H31N3O11
CAS Registry Number 113786-33-7
SMILES C1=CC=C(C=C1)COCC(C(=O)O)N(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Migraine17.14.02.001; 24.03.05.003---
Monocyte count increased13.01.06.009---
Monocytosis01.02.01.004---
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Myocardial ischaemia02.02.02.008; 24.04.04.010---
Myositis15.05.01.001--
Nasal congestion22.04.04.001--
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.001--
Necrosis08.03.03.001; 24.04.02.006---
Nervous system disorder17.02.10.001---
Night sweats08.01.03.031; 23.02.03.006---
Ocular hyperaemia06.04.05.004---
Oculomucocutaneous syndrome06.04.05.014; 07.05.01.010; 23.03.01.022---
Oedema mouth07.05.04.001; 10.01.05.006; 23.04.01.008---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Palpitations02.11.04.012--
Pancreatitis necrotising07.18.01.004---
Paraesthesia17.02.06.005; 23.03.03.094--
Paralysis17.01.04.004---
Parosmia17.04.04.002; 22.04.03.007---
Phlebitis12.02.01.002; 24.12.03.004--
Pollakiuria20.02.02.007--
Proteinuria20.02.01.011--
Pruritus23.03.12.001--
Pulmonary congestion02.05.02.002; 22.01.03.002; 24.03.08.001---
Pulmonary embolism22.06.02.001; 24.01.06.001---
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