Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gadobenate dimeglumine
Drug ID BADD_D00983
Description Gadobenic acid (in the form of gadobenate dimeglumine) is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for visualizing the CNS and heart. In contrast to conventional extracellular fluid contrast agents, gadobenate dimeglumine is characterized by a weak and transient binding capacity to serum proteins. This binding leads to an increased relaxivity of gadobenate dimeglumine and, consequently, to a considerably increased signal intensity over that of other agents.
Indications and Usage Gadobenate Dimeglumine is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for MRI of the heart, as well as and central nervous system in adults to visualize lesions with abnormal brain vascularity or abnormalities in the blood brain barrier, the brain, spine, or other associated tissues.
Marketing Status approved; investigational
ATC Code V08CA08
DrugBank ID DB00743
KEGG ID D04283
MeSH ID C064572
PubChem ID 105125
TTD Drug ID D01OIL
NDC Product Code 57876-333; 0270-5164; 0270-5264
UNII 3Q6PPC19PO
Synonyms gadobenic acid | 3,6,9-triaza-12-oxa-3,6,9-tricarboxymethylene-10-carboxy-13-phenyltridecanoic acid, gadolinium | Gd-BOPTA | gadobenic acid, dimeglumine salt | gadobenate dimeglumine | gadolinium-BOPTA-Dimeg | MultiHance | Gd(BOPTA)2 | B 19036 | B-19036 | gadolinium-benzyloxypropionyl tetraacetate
Chemical Information
Molecular Formula C22H31N3O11
CAS Registry Number 113786-33-7
SMILES C1=CC=C(C=C1)COCC(C(=O)O)N(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypochromic anaemia01.03.02.004---
Hypoglycaemia05.06.03.001; 14.06.03.001--
Hyponatraemia14.05.04.002--
Hypoproteinaemia09.01.02.004; 14.10.01.003---
Hypotension24.06.03.002--
Immune system disorder10.02.01.001---
Infection11.01.08.002---
Injection site erythema08.02.03.001; 12.07.03.001; 23.03.06.015---
Injection site extravasation08.02.03.002; 12.07.03.002---
Injection site haemorrhage08.02.03.005; 12.07.03.005; 24.07.01.010---
Injection site inflammation08.02.03.008; 12.07.03.009---
Injection site pain08.02.03.010; 12.07.03.011---
Injection site reaction08.02.03.014; 12.07.03.015--
Injection site vesicles08.02.03.051; 12.07.03.051; 23.03.01.024---
Injection site warmth08.02.03.036; 12.07.03.036---
Intracranial pressure increased17.07.02.002---
Iron binding capacity total13.11.01.037---
Laboratory test abnormal13.18.01.001---
Laryngeal oedema10.01.05.003; 22.04.02.001; 23.04.01.005--
Laryngospasm22.04.02.002--
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001---
Ligament sprain12.01.07.008; 15.07.02.004---
Liver disorder09.01.08.001---
Liver function test abnormal13.03.04.030---
Loss of consciousness17.02.04.004---
Lung disorder22.02.07.001---
Lymphocyte count increased13.01.06.007--
Malaise08.01.01.003--
Micturition urgency20.02.02.006--
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