Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluvoxamine
Drug ID BADD_D00950
Description Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database comprised of approximately 35,000 patients. It was launched in the US in December 1994 and in Japan in June 1999. As of the end of 1995, more than 10 million patients worldwide have been treated with fluvoxamine.
Indications and Usage Indicated predominantly for the management of depression and for Obsessive Compulsive Disorder (OCD) [FDA Label]. Has also been used in the management of bulimia nervosa [A250].
Marketing Status approved; investigational
ATC Code N06AB08
DrugBank ID DB00176
KEGG ID D07984
MeSH ID D016666
PubChem ID 5324346
TTD Drug ID D03HFG
NDC Product Code Not Available
UNII O4L1XPO44W
Synonyms Fluvoxamine | Fluvoxadura | Fluvoxamin AL | Fluvoxamin beta | Fluvoxamin Stada | Fluvoxamin-neuraxpharm | Fluvoxamin neuraxpharm | Fluvoxamin-ratiopharm | Fluvoxamin ratiopharm | ratio-Fluvoxamine | ratio Fluvoxamine | Fluvoxamina Geminis | Geminis, Fluvoxamina | Fluvoxamine Maleate | Fluvoxamine Maleate, (E)-Isomer | Fluvoxamine, (Z)-Isomer | Luvox | Floxyfral | Fevarin | Dumirox | Faverin | Novo-Fluvoxamine | Novo Fluvoxamine | Nu-Fluvoxamine | Nu Fluvoxamine | PMS-Fluvoxamine | PMS Fluvoxamine | Desiflu | DU-23000 | DU 23000 | DU23000
Chemical Information
Molecular Formula C15H21F3N2O2
CAS Registry Number 54739-18-3
SMILES COCCCCC(=NOCCN)C1=CC=C(C=C1)C(F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Renal failure20.01.03.005---
Renal pain20.02.03.003---
Retinal detachment06.09.03.003; 12.01.04.004--
Rhabdomyolysis15.05.05.0020.000937%
Rheumatoid arthritis10.04.06.001; 15.01.03.001---
Rhinitis11.01.13.004; 22.07.03.006--
Salivary hypersecretion07.06.01.009---
Schizophreniform disorder19.03.02.001---
Screaming08.01.03.099; 19.04.02.020---
Seborrhoeic dermatitis23.03.04.018---
Seizure17.12.03.001--
Serotonin syndrome12.03.01.041; 15.05.04.016; 17.05.02.004---
Sexual dysfunction19.08.05.002; 21.03.02.003---
Shock24.06.02.002---
Sinusitis11.01.13.005; 22.07.03.007--
Skin discolouration23.03.03.005---
Sleep disorder19.02.04.001---
Somnolence17.02.04.006; 19.02.05.0030.000937%
Somnolence neonatal17.02.04.017; 18.04.04.007; 19.02.05.007---
Stevens-Johnson syndrome10.01.01.045; 11.07.01.005; 12.03.01.014; 23.03.01.007--
Stomatitis07.05.06.005--
Stupor17.02.04.007; 19.02.05.004---
Sudden death02.03.04.013; 08.04.01.003--
Suicidal ideation19.12.01.003--
Suicide attempt19.12.01.004--
Supraventricular extrasystoles02.03.03.011---
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Tachycardia02.03.02.007---
Tardive dyskinesia17.01.02.012---
Tendinous contracture15.07.01.001---
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ADReCS-Target
Drug Name ADR Term Target
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