Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Flurbiprofen
Drug ID BADD_D00941
Description Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
Indications and Usage Flurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis. It may also be used to treat pain associated with dysmenorrhea and mild to moderate pain accompanied by inflammation (e.g. bursitis, tendonitis, soft tissue trauma). Topical ophthalmic formulations may be used pre-operatively to prevent intraoperative miosis.
Marketing Status approved; investigational
ATC Code M01AE09; M02AA19; R02AX01; S01BC04
DrugBank ID DB00712
KEGG ID D00330
MeSH ID D005480
PubChem ID 3394
TTD Drug ID D0A1PX
NDC Product Code 49452-3178; 71574-111; 22568-1093; 38779-2739; 51552-0818; 51927-0008; 55545-0405; 63629-8338; 0093-0711; 63629-8808; 51686-0004; 66577-029; 51927-0219; 62991-3064; 17511-123; 61891-001; 62756-510; 68788-7341; 63275-9913; 43063-992
UNII 5GRO578KLP
Synonyms Flurbiprofen | 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic Acid | Flubiprofen | Fluriproben | Dobrofen | E-7869 | E 7869 | E7869 | Nu-Flurbiprofen | Nu Flurbiprofen | Ocufen | ratio-Flurbiprofen | ratio Flurbiprofen | Strefen | Flugalin | Flurbiprofen Sodium | Froben | Neo Artrol | Novo-Flurprofen | Novo Flurprofen | Ansaid | Apo-Flurbiprofen | Apo Flurbiprofen | BTS-18322 | BTS 18322 | BTS18322 | Cebutid | Froben SR | Ocuflur
Chemical Information
Molecular Formula C15H13FO2
CAS Registry Number 5104-49-4
SMILES CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Premature delivery18.07.01.0060.002389%
Prostatic disorder21.04.01.001---
Proteinuria20.02.01.011--
Pruritus23.03.12.0010.003583%
Pulmonary embolism22.06.02.001; 24.01.06.001---
Pulmonary infarction22.06.02.002; 24.04.09.001---
Purpura01.01.04.003; 23.06.01.004; 24.07.06.005--
Pyrexia08.05.02.0030.002389%
Pyuria11.01.08.043; 20.08.02.016---
Rash23.03.13.001---
Rectal haemorrhage07.12.03.001; 24.07.02.018--
Renal failure20.01.03.005---
Respiratory depression17.02.05.047; 22.02.01.010---
Retinal haemorrhage06.10.01.001; 24.07.05.003---
Rhinitis11.01.13.004; 22.07.03.006--
Rhinorrhoea22.12.03.0210.003583%
Right ventricular failure02.05.03.002---
Scleritis06.04.07.002; 10.02.01.025---
Seborrhoeic dermatitis23.03.04.018---
Seizure17.12.03.001--
Sepsis11.01.11.003--
Shock24.06.02.002---
Sinusitis11.01.13.005; 22.07.03.007--
Skin exfoliation23.03.07.003---
Skin ulcer23.07.03.003; 24.04.03.007--
Somnolence17.02.04.006; 19.02.05.0030.002389%
Speech disorder17.02.08.003; 19.19.02.002; 22.12.03.027---
Stevens-Johnson syndrome10.01.01.045; 11.07.01.005; 12.03.01.014; 23.03.01.007--
Stomatitis07.05.06.005--
Subarachnoid haemorrhage12.01.10.011; 17.08.01.010; 24.07.04.004---
The 7th Page    First    Pre   7 8 9 10    Next   Last    Total 10 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene