Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Flurbiprofen
Drug ID BADD_D00941
Description Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
Indications and Usage Flurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis. It may also be used to treat pain associated with dysmenorrhea and mild to moderate pain accompanied by inflammation (e.g. bursitis, tendonitis, soft tissue trauma). Topical ophthalmic formulations may be used pre-operatively to prevent intraoperative miosis.
Marketing Status approved; investigational
ATC Code M01AE09; M02AA19; R02AX01; S01BC04
DrugBank ID DB00712
KEGG ID D00330
MeSH ID D005480
PubChem ID 3394
TTD Drug ID D0A1PX
NDC Product Code 49452-3178; 71574-111; 22568-1093; 38779-2739; 51552-0818; 51927-0008; 55545-0405; 63629-8338; 0093-0711; 63629-8808; 51686-0004; 66577-029; 51927-0219; 62991-3064; 17511-123; 61891-001; 62756-510; 68788-7341; 63275-9913; 43063-992
UNII 5GRO578KLP
Synonyms Flurbiprofen | 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic Acid | Flubiprofen | Fluriproben | Dobrofen | E-7869 | E 7869 | E7869 | Nu-Flurbiprofen | Nu Flurbiprofen | Ocufen | ratio-Flurbiprofen | ratio Flurbiprofen | Strefen | Flugalin | Flurbiprofen Sodium | Froben | Neo Artrol | Novo-Flurprofen | Novo Flurprofen | Ansaid | Apo-Flurbiprofen | Apo Flurbiprofen | BTS-18322 | BTS 18322 | BTS18322 | Cebutid | Froben SR | Ocuflur
Chemical Information
Molecular Formula C15H13FO2
CAS Registry Number 5104-49-4
SMILES CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nail disorder23.02.05.002--
Nasal congestion22.04.04.0010.002389%
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Nervous system disorder17.02.10.001---
Nervousness19.06.02.003---
Neuralgia17.02.07.005--
Neutropenia01.02.03.004---
Ocular hyperaemia06.04.05.004---
Oedema08.01.07.006; 14.05.06.0100.002389%-
Oesophagitis07.08.05.001--
Oliguria20.01.03.004---
Optic neuritis06.04.08.002; 10.02.01.097; 17.04.05.001---
Osteoarthritis15.01.04.001---
Pain08.01.08.004--
Palpitations02.11.04.012--
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.003---
Paraesthesia17.02.06.005; 23.03.03.094--
Parosmia17.04.04.002; 22.04.03.007---
Peptic ulcer07.04.07.001---
Periorbital oedema06.08.03.017; 10.01.05.010; 23.04.01.0020.003583%
Petechiae01.01.03.002; 23.06.01.003; 24.07.06.004---
Pharyngeal oedema10.01.05.016; 22.04.05.003; 23.04.01.0160.002389%-
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Phlebitis12.02.01.002; 24.12.03.004--
Photophobia06.01.01.004; 17.17.02.006--
Photosensitivity reaction23.03.09.003--
Pneumonia11.01.09.003; 22.07.01.003---
Polyuria20.02.03.002---
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ADReCS-Target
Drug Name ADR Term Target
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