| Drug Name |
Felodipine |
| Drug ID |
BADD_D00872 |
| Description |
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension. |
| Indications and Usage |
For the treatment of mild to moderate essential hypertension. |
| Marketing Status |
approved; investigational |
| ATC Code |
C08CA02 |
| DrugBank ID |
DB01023
|
| KEGG ID |
D00319
|
| MeSH ID |
D015736
|
| PubChem ID |
3333
|
| TTD Drug ID |
D0WN0U
|
| NDC Product Code |
13668-134; 53489-368; 53489-369; 53489-370; 63629-2018; 53104-7519; 63629-2017; 69367-266; 0603-3581; 0603-3582; 65862-399; 66406-0276; 63629-2196; 63629-9301; 0603-3583; 57237-110; 61442-432; 63629-2016; 65862-673; 65862-675; 69367-265; 71205-922; 72162-1159; 62135-646; 69367-264; 14799-2007; 66406-0277; 13668-133; 51407-087; 51407-089; 57237-109; 61442-433; 62135-647; 13668-132; 50090-5870; 57237-108; 63629-2191; 63629-2194; 68462-233; 68462-234; 53296-0041; 23155-049; 51407-088; 61442-431; 62135-648; 63629-2195; 65862-674; 68462-235; 71335-1486; 71335-2175; 72162-1158; 72162-1160; 66406-0275; 63629-2193; 71205-920; 23155-048; 63629-2192; 71205-921; 71335-1318; 65035-105; 23155-050 |
| UNII |
OL961R6O2C
|
| Synonyms |
Felodipine | Felo Biochemie | Felo-Puren | Felo Puren | Felobeta | Felocor | Felodipin 1A Pharma | Felodipin AbZ | Felodipin AL | Felodipin AZU | Felodipin Dura | Felodipin Heumann | Heumann, Felodipin | Felodipin Stada | Felodipin Von Ct | Von Ct, Felodipin | Felodipin-Ratiopharm | Felodipin Ratiopharm | Felodur | Felogamma | Fensel | H 154-82 | H 154 82 | H 15482 | Perfudal | Plendil | Flodil | Modip | Renedil | Munobal | Agon |
