Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Felodipine
Drug ID BADD_D00872
Description Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Indications and Usage For the treatment of mild to moderate essential hypertension.
Marketing Status Prescription; Discontinued
ATC Code C08CA02
DrugBank ID DB01023
KEGG ID D00319
MeSH ID D015736
PubChem ID 3333
TTD Drug ID D0WN0U
NDC Product Code 53489-369; 63629-2017; 63629-2194; 71205-922; 53296-0041; 23155-048; 51407-088; 65862-674; 50090-5870; 13668-132; 63629-2193; 63629-2191; 66406-0275; 23155-050; 65862-673; 61442-432; 61442-431; 63629-2018; 71335-1486; 50090-2421; 64679-412; 71335-1318; 65862-399; 51407-087; 57237-109; 63629-2192; 66406-0276; 65035-105; 53104-7519; 0603-3582; 0603-3583; 13668-133; 14799-2007; 63629-2016; 53489-368; 23155-049; 57237-110; 63629-2196; 64679-414; 58657-685; 66406-0277; 61442-433; 13668-134; 57237-108; 65862-675; 46708-926; 68462-233; 63629-2195; 58657-687; 51407-089; 68462-235; 53489-370; 68462-234; 71205-921; 71205-920; 58657-686; 64679-411; 0603-3581
Synonyms Felodipine | Felo Biochemie | Felo-Puren | Felo Puren | Felobeta | Felocor | Felodipin 1A Pharma | Felodipin AbZ | Felodipin AL | Felodipin AZU | Felodipin Dura | Felodipin Heumann | Heumann, Felodipin | Felodipin Stada | Felodipin Von Ct | Von Ct, Felodipin | Felodipin-Ratiopharm | Felodipin Ratiopharm | Felodur | Felogamma | Fensel | H 154-82 | H 154 82 | H 15482 | Perfudal | Plendil | Flodil | Modip | Renedil | Munobal | Agon
Chemical Information
Molecular Formula C18H19Cl2NO4
CAS Registry Number 72509-76-3
SMILES CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Acne23.02.01.0010.001599%Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.0010.003997%
Anaemia01.03.02.001--
Anaphylactoid reaction10.01.07.003; 24.06.03.0070.005596%Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema10.01.05.009; 23.04.01.0010.002398%Not Available
Anxiety19.06.02.0020.003997%
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Atrioventricular block second degree02.03.01.005--
Back pain15.03.04.005--
Blister12.01.06.002; 23.03.01.0010.001599%Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain02.02.02.011; 08.01.08.002; 22.02.08.0030.002398%Not Available
Coma17.02.09.0010.001599%Not Available
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Cough22.02.03.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.0070.006396%
Dry mouth07.06.01.002--
The 1th Page    1 2 3 4 5    Next   Last    Total 5 Pages