Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Felodipine
Drug ID BADD_D00872
Description Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.
Indications and Usage For the treatment of mild to moderate essential hypertension.
Marketing Status approved; investigational
ATC Code C08CA02
DrugBank ID DB01023
KEGG ID D00319
MeSH ID D015736
PubChem ID 3333
TTD Drug ID D0WN0U
NDC Product Code 13668-134; 53489-368; 53489-369; 53489-370; 63629-2018; 53104-7519; 63629-2017; 69367-266; 0603-3581; 0603-3582; 65862-399; 66406-0276; 63629-2196; 63629-9301; 0603-3583; 57237-110; 61442-432; 63629-2016; 65862-673; 65862-675; 69367-265; 71205-922; 72162-1159; 62135-646; 69367-264; 14799-2007; 66406-0277; 13668-133; 51407-087; 51407-089; 57237-109; 61442-433; 62135-647; 13668-132; 50090-5870; 57237-108; 63629-2191; 63629-2194; 68462-233; 68462-234; 53296-0041; 23155-049; 51407-088; 61442-431; 62135-648; 63629-2195; 65862-674; 68462-235; 71335-1486; 71335-2175; 72162-1158; 72162-1160; 66406-0275; 63629-2193; 71205-920; 23155-048; 63629-2192; 71205-921; 71335-1318; 65035-105; 23155-050
UNII OL961R6O2C
Synonyms Felodipine | Felo Biochemie | Felo-Puren | Felo Puren | Felobeta | Felocor | Felodipin 1A Pharma | Felodipin AbZ | Felodipin AL | Felodipin AZU | Felodipin Dura | Felodipin Heumann | Heumann, Felodipin | Felodipin Stada | Felodipin Von Ct | Von Ct, Felodipin | Felodipin-Ratiopharm | Felodipin Ratiopharm | Felodur | Felogamma | Fensel | H 154-82 | H 154 82 | H 15482 | Perfudal | Plendil | Flodil | Modip | Renedil | Munobal | Agon
Chemical Information
Molecular Formula C18H19Cl2NO4
CAS Registry Number 72509-76-3
SMILES CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.002--
Acne23.02.01.0010.000357%-
Alanine aminotransferase increased13.03.04.005--
Alopecia23.02.02.0010.000893%
Anaemia01.03.02.001--
Anaphylactoid reaction10.01.07.003; 24.06.03.0070.000893%-
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.0010.000357%-
Arrhythmia02.03.02.001---
Arthralgia15.01.02.001--
Asthenia08.01.01.001---
Atrioventricular block second degree02.03.01.005--
Back pain15.03.04.005--
Blood pressure fluctuation24.06.01.002---
Body temperature increased13.15.01.001---
Bradycardia02.03.02.002---
Bronchitis11.01.09.001; 22.07.01.001--
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.0020.000357%-
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.0030.000714%-
Condition aggravated08.01.03.004---
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Cough22.02.03.001--
Depression19.15.01.001--
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.001429%
Drug ineffective08.06.01.006---
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