Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ezogabine
Drug ID BADD_D00865
Description Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients with refractory epilepsy. FDA approved in June 10, 2011 under the name of ezogabine.
Indications and Usage Adjuvant treatment of partial-onset seizures.
Marketing Status approved; investigational
ATC Code N03AX21
DrugBank ID DB04953
KEGG ID D09569
MeSH ID C101866
PubChem ID 121892
TTD Drug ID D0X7GL
NDC Product Code Not Available
UNII 12G01I6BBU
Synonyms ezogabine | retigabine | N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester | D 20443 | D-20443 | Potiga | D 23129 | D-23129 | ethyl N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamate hydrochloride
Chemical Information
Molecular Formula C16H18FN3O2
CAS Registry Number 150812-12-7
SMILES CCOC(=O)NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Hallucination19.10.04.003--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypokinesia17.01.02.009---
Increased appetite08.01.09.027; 14.03.01.003---
Infection11.01.08.002---
Influenza11.05.03.001; 22.07.02.001---
Leukopenia01.02.02.001---
Liver function test abnormal13.03.04.030---
Loss of consciousness17.02.04.004---
Malaise08.01.01.003--
Memory impairment17.03.02.003; 19.20.01.003--
Muscle spasms15.05.03.004--
Myoclonus17.02.05.008---
Nail discolouration23.02.05.001--
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Nervous system disorder17.02.10.001---
Neutropenia01.02.03.004---
Nystagmus06.05.02.006; 17.02.02.006--
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Osteoarthritis15.01.04.001---
Paraesthesia17.02.06.005; 23.03.03.094--
Rash23.03.13.001---
Renal colic20.02.03.010--
Shock24.06.02.002---
Skin discolouration23.03.03.005---
Somnolence17.02.04.006; 19.02.05.003--
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Thrombocytopenia01.08.01.002---
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