| Pharmaceutical Information |
| Drug Name |
Extendin-4 |
| Drug ID |
BADD_D00863 |
| Description |
Exenatide is a glucagon-like peptide-1 (GLP-1) analog[Label]. It functions to activate the GLP-1 receptor and increases insulin secretion, decrease glucagon secretion, and slow gastric emptying to improve glycemic control[Label]. Exenatide was given FDA approval on April 28, 2005[L6106]. |
| Indications and Usage |
Exenatide is indicated for improving glycemic control in adults with type 2 diabetes mellitus along with diet and exercise[Label]. |
| Marketing Status |
approved; investigational |
| ATC Code |
A10BJ01 |
| DrugBank ID |
DB01276
|
| KEGG ID |
D04121
|
| MeSH ID |
D000077270
|
| PubChem ID |
16157882
|
| TTD Drug ID |
D00YVF
|
| NDC Product Code |
52416-125; 0310-6540; 41524-0003; 69766-078; 68067-0397; 0310-6512; 0310-6524; 52416-105; 0406-7310; 59149-004 |
| UNII |
9P1872D4OL
|
| Synonyms |
Exenatide | Bydureon | ITCA 650 | AC 2993 LAR | Exendin-4 | Ex4 Peptide | Peptide, Ex4 | Exendin 4 | Byetta | AC 2993 |
|
| Chemical Information |
| Molecular Formula |
C184H282N50O60S |
| CAS Registry Number |
141758-74-9 |
| SMILES |
CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(CCCCN
)C(=O)NC(CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCCC3C(=O)NC(CO)C(=O)NC(CO)C(=O)NCC(=O)NC(
C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N6CCCC6C(=O)NC(CO)C(=O)N)NC(=O)C(CC7=CC=CC=C7)NC(
=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(
CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CO
)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC8=CC=CC=C8)NC
(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CC9=CN=CN9)N |
| Chemical Structure |
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| ADRs Induced by Drug |
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