Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Exemestane
Drug ID BADD_D00861
Description Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Indications and Usage For the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
Marketing Status approved; investigational
ATC Code L02BG06
DrugBank ID DB00990
KEGG ID D00963
MeSH ID C056516
PubChem ID 60198
TTD Drug ID D0D2VS
NDC Product Code 62157-091; 65129-1217; 44278-025; 71921-190; 51552-1619; 65427-030; 68724-1003; 51991-005; 63629-2056; 68382-383; 49386-026; 73377-132; 46439-8746; 59762-2858; 70771-1374; 65162-240; 0054-0080; 69097-316; 59057-007; 64918-0622; 64181-0005; 59651-516; 52128-134; 64918-0621; 53104-7666; 59057-008; 0832-0595; 65089-0046; 0009-7663
UNII NY22HMQ4BX
Synonyms exemestane | examestane | 6-methyleneandrosta-1,4-diene-3,17-dione | FCE 24304 | FCE-24304 | Aromasil | Aromasin | Aromasine
Chemical Information
Molecular Formula C20H24O2
CAS Registry Number 107868-30-4
SMILES CC12CCC3C(C1CCC2=O)CC(=C)C4=CC(=O)C=CC34C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Swelling face08.01.03.100; 10.01.05.018; 23.04.01.0180.004078%-
Tachycardia02.03.02.007---
Tenderness08.01.08.0050.001046%-
Tendonitis12.01.07.007; 15.07.01.003---
Therapeutic response unexpected08.06.01.0010.004078%-
Thinking abnormal17.02.05.023; 19.10.03.0010.003555%-
Thrombocytopenia01.08.01.002---
Thrombosis24.01.01.0060.005751%-
Tinnitus04.04.01.002; 17.04.07.0040.005856%
Transient ischaemic attack17.08.04.001; 24.04.06.0050.001568%
Trigger finger15.07.01.0050.002300%-
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urinary tract infection11.01.14.004; 20.08.02.001--
Urticaria10.01.06.001; 23.04.02.001--
Uterine haemorrhage21.07.01.005; 24.07.03.004--
Uterine polyp16.04.02.002; 21.07.02.001---
Vaginal haemorrhage21.08.01.001; 24.07.03.0050.004705%
Varicose vein24.10.04.0010.001046%-
Viral infection11.05.04.001---
Visual impairment06.02.10.0130.006379%-
Vomiting07.01.07.003--
Vulvovaginal dryness21.08.02.003--
Weight increased13.15.01.006--
Musculoskeletal disorder15.03.05.0250.004078%-
Acute generalised exanthematous pustulosis10.01.01.034; 11.07.01.018; 12.03.01.005; 23.03.10.002---
Hypoacusis04.02.01.0060.008156%
Peripheral swelling02.05.04.015; 08.01.03.0530.012966%-
Osteopenia14.04.04.004; 15.02.03.0030.005647%-
Left ventricular hypertrophy02.04.02.0140.001046%-
Balance disorder08.01.03.081; 17.02.02.0070.004601%-
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ADReCS-Target
Drug Name ADR Term Target
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