Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etoricoxib
Drug ID BADD_D00856
Description Etoricoxib is a new COX-2 selective inhibitor. Current therapeutic indications are: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Like any other COX-2 selective inhibitor, Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2) to reduce the generation of prostaglandins (PGs) from arachidonic acid. It is approved in more than 60 countries worldwide but not in the US.
Indications and Usage For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.
Marketing Status approved; investigational
ATC Code M01AH05
DrugBank ID DB01628
KEGG ID D03710
MeSH ID D000077613
PubChem ID 123619
TTD Drug ID D09MGR
NDC Product Code 42765-006; 68554-0053
UNII WRX4NFY03R
Synonyms Etoricoxib | MK 0663 | MK-0663 | MK0663 | Arcoxia | L-791456 | L 791456 | L791456
Chemical Information
Molecular Formula C18H15ClN2O2S
CAS Registry Number 202409-33-4
SMILES CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ecchymosis01.01.03.001; 23.06.01.001; 24.07.06.002---
Eczema23.03.04.006--
Epistaxis22.04.03.001; 24.07.01.005--
Erythema23.03.06.001---
Erythema multiforme10.01.03.015; 23.03.01.003--
Eye disorder06.08.03.001---
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014---
Flatulence07.01.04.002--
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Folliculitis11.02.01.053; 23.11.04.003--
Fungal infection11.03.05.001---
Gamma-glutamyltransferase increased13.03.04.024--
Gastritis07.08.02.001--
Gastrooesophageal reflux disease07.02.02.003--
Gastroenteritis07.19.03.001; 11.01.07.004---
Gastrointestinal disorder07.11.01.001---
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009---
Gastrointestinal pain07.01.05.005--
Gingival disorder07.09.13.004---
Glycosuria20.02.01.005--
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Blood urine present13.13.02.002---
Haemoglobin13.01.05.018---
Haemorrhoids07.15.03.001; 24.10.02.002--
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatic steatosis09.01.07.003; 14.08.04.005---
Hepatitis09.01.07.004---
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