Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Etodolac
Drug ID BADD_D00850
Description Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.
Indications and Usage For acute and long-term management of signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as for the management of pain.
Marketing Status approved; investigational; vet_approved
ATC Code M01AB08
DrugBank ID DB00749
KEGG ID D00315
MeSH ID D017308
PubChem ID 3308
TTD Drug ID D0N1WU
NDC Product Code 80425-0126; 80425-0140; 17373-0186; 16714-497; 0093-1118; 43063-856; 0185-0687; 51655-166; 80425-0190; 17373-0187; 42799-112; 50090-1790; 50090-3974; 51672-4017; 55700-592; 60429-313; 60760-378; 61919-858; 62559-251; 63629-1935; 63629-8598; 70518-3116; 71335-0399; 71335-1958; 0093-1122; 51672-4051; 60429-311; 60429-315; 60760-552; 61919-092; 68382-272; 70518-3163; 65841-779; 71205-140; 71205-743; 58793-010; 67628-1001; 42291-405; 69238-1343; 71205-467; 16714-499; 43063-671; 0185-0675; 51672-4036; 60429-243; 60429-312; 60505-0040; 61919-251; 62559-250; 63187-736; 68788-7315; 69238-1342; 69306-020; 83221-003; 43353-294; 51672-4018; 63629-3641; 63629-8805; 71335-0126; 71335-0602; 76385-119; 80425-0181; 42291-404; 43063-578; 50090-1789; 51672-4053; 60429-244; 60505-0039; 63187-374; 63187-793; 63629-1936; 68382-271; 76385-118; 57451-1161; 16714-498; 42799-111; 51655-735; 55700-757; 60429-314; 60505-0102; 60760-298; 65841-777; 68788-7300; 0093-7172; 50090-2132; 50090-2133; 51672-4052; 60505-0041; 65841-778; 67296-1271; 68382-273; 71335-0982; 71335-1230; 43063-834; 50090-3963; 51672-4016
UNII 2M36281008
Synonyms Etodolac | Etodolic Acid | Etodolac, (+-)-Isomer | Etodolac, (-)-Isomer | Etodolac, (S)-Isomer | Ultradol | Etodolac, Monosodium Salt, (+-) Isomer | Etodolac, Monosodium Salt, (S)-Isomer | Lodine | Ramodar | AY-24,236 | AY 24,236 | AY-24236 | AY 24236 | Etodolac, Monosodium Salt
Chemical Information
Molecular Formula C17H21NO3
CAS Registry Number 41340-25-4
SMILES CCC1=C2C(=CC=C1)C3=C(N2)C(OCC3)(CC)CC(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Protein urine present13.13.02.006---
Musculoskeletal discomfort15.03.04.001---
Haemorrhage24.07.01.0020.000755%-
Colitis microscopic07.08.01.0110.000354%-
Epidermal necrosis23.03.03.035---
Urine output increased13.13.03.002---
Hepatic enzyme increased13.03.04.028---
Decreased appetite08.01.09.028; 14.03.01.005--
Gastrointestinal ulcer07.04.04.002---
Ill-defined disorder08.01.03.049---
Pulmonary function test decreased13.19.01.001---
Renal impairment20.01.03.010---
Cystitis noninfective20.03.02.001--
Oropharyngeal discomfort07.05.05.008; 22.12.03.0150.000236%-
Oropharyngeal pain07.05.05.004; 22.12.03.0160.000354%
Acute kidney injury20.01.03.0160.000637%
Drug-induced liver injury09.01.07.023; 12.03.01.0440.000472%-
Perforation08.01.03.058---
Dermatitis exfoliative generalised10.01.01.029; 23.03.07.0020.000236%-
Haemophagocytic lymphohistiocytosis01.05.01.026; 10.02.01.077; 16.32.03.0380.000472%-
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