Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Ethionamide
Drug ID BADD_D00845
Description A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Indications and Usage For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
Marketing Status approved
ATC Code J04AD03
DrugBank ID DB00609
KEGG ID D00591
MeSH ID D005000
PubChem ID 2761171
TTD Drug ID D0P0HB
NDC Product Code 0008-4117
UNII OAY8ORS3CQ
Synonyms Ethionamide | Ethioniamide | Amidazine | Trecator | Trecator-SC | Trecator SC
Chemical Information
Molecular Formula C8H10N2S
CAS Registry Number 536-33-4
SMILES CCC1=NC=CC(=C1)C(=S)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acne23.02.01.001---
Agitation17.02.05.012; 19.06.02.001--
Alanine aminotransferase increased13.03.04.005--
Aspartate aminotransferase increased13.03.04.011--
Blood bilirubin increased13.03.04.018--
Depression19.15.01.001--
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Diplopia06.02.06.002; 17.17.01.005---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspepsia07.01.02.001--
Gastrointestinal disorder07.11.01.001---
Gastrointestinal pain07.01.05.005--
Gynaecomastia05.05.02.003; 21.05.04.003--
Headache17.14.01.001--
Hepatitis09.01.07.004---
Hypersensitivity10.01.03.003--
Hypoglycaemia05.06.03.001; 14.06.03.001--
Hypothyroidism05.02.03.001; 14.11.01.012--
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Nausea07.01.07.001--
Neuritis17.09.03.001---
Neuropathy peripheral17.09.03.003---
Neurotoxicity12.03.01.011; 17.02.10.002---
Nicotinic acid deficiency14.12.02.002; 23.03.04.013---
Optic neuritis06.04.08.002; 10.02.01.097; 17.04.05.001---
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Photosensitivity reaction23.03.09.003--
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ADReCS-Target
Drug Name ADR Term Target
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