Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Ethionamide
Drug ID BADD_D00845
Description A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Indications and Usage For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
Marketing Status Prescription
ATC Code J04AD03
DrugBank ID DB00609
KEGG ID D00591
MeSH ID D005000
PubChem ID 2761171
TTD Drug ID D0P0HB
NDC Product Code 0008-4117
Synonyms Ethionamide | Ethioniamide | Amidazine | Trecator | Trecator-SC | Trecator SC
Chemical Information
Molecular Formula C8H10N2S
CAS Registry Number 536-33-4
SMILES CCC1=NC=CC(=C1)C(=S)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acne23.02.01.001--Not Available
Agitation17.02.05.012; 19.06.02.001--
Alanine aminotransferase increased13.03.01.003--
Aspartate aminotransferase increased13.03.01.006--
Blood bilirubin increased13.03.01.008--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Diplopia06.02.06.002; 17.17.01.005--Not Available
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.007--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspepsia07.01.02.001--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Gynaecomastia05.05.02.003; 21.05.04.003--
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hypersensitivity10.01.03.003--
Hypoglycaemia05.06.03.001; 14.06.03.001--
Hypothyroidism05.02.03.001; 14.11.01.012--
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030--Not Available
Nausea07.01.07.001--
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neurotoxicity12.03.01.011; 17.02.10.002--Not Available
Nicotinic acid deficiency14.12.02.002; 23.03.04.013--Not Available
Optic neuritis06.04.08.002; 10.04.10.002; 17.04.05.001--Not Available
Orthostatic hypotension17.05.01.020; 24.06.03.004--Not Available
Photosensitivity reaction23.03.09.003--
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ADReCS-Target
Drug Name ADR Term Target
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