Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ethambutol hydrochloride
Drug ID BADD_D00842
Description Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis.[L31743] Ethambutol was first described in the literature in 1961.[A229048] It was developed out of a need for therapies active against isoniazid resistant strains of _Mycobacterium tuberculosis_.[A229048] Ethambutol was granted FDA approval on 6 November 1967.[L31663]
Indications and Usage Ethambutol is indicated in combination with other anti-tuberculosis drugs in the treatment of pulmonary tuberculosis.[L31663] Ethambutol is commonly used in combination with [isoniazid], [rifampin], and [pyrazinamide].[L31743]
Marketing Status approved
ATC Code J04AK02
DrugBank ID DB00330
KEGG ID D00878
MeSH ID D004977
PubChem ID 14051
TTD Drug ID D08QME
NDC Product Code 42806-102; 68850-012; 68180-280; 68850-010; 70518-3662; 42806-101; 54879-002; 68084-280; 65691-0014; 68180-281; 70518-2691; 66406-0224; 50090-5140; 70518-2966; 54879-001
UNII QE4VW5FO07
Synonyms Ethambutol | Dexambutol | Etibi | EMB-Fatol | EMB Fatol | Etambutol Llorente | Llorente, Etambutol | Ethambutol Hydrochloride | Hydrochloride, Ethambutol | Myambutol | Miambutol | EMB-Hefa | EMB Hefa
Chemical Information
Molecular Formula C10H26Cl2N2O2
CAS Registry Number 1070-11-7
SMILES CCC(CO)NCCNC(CC)CO.Cl.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.002--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Arthralgia15.01.02.001--
Blindness06.02.10.003; 17.17.01.003---
Blood uric acid increased13.02.04.001---
Body temperature increased13.15.01.001---
Colour blindness03.01.01.001; 06.02.09.001---
Confusional state17.02.03.005; 19.13.01.001--
Dermatitis23.03.04.002---
Dermatitis allergic10.01.03.014; 23.03.04.003---
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Discomfort08.01.08.003---
Disorientation17.02.05.015; 19.13.01.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Eosinophilia01.02.04.001--
Erythema multiforme10.01.03.015; 23.03.01.003--
Feeling abnormal08.01.09.014---
Gastrointestinal pain07.01.05.005--
Gout14.09.01.001; 15.01.06.001---
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001---
Hepatitis09.01.07.004---
Hepatotoxicity09.01.07.009; 12.03.01.008---
Hypersensitivity10.01.03.003--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Leukopenia01.02.02.001---
Liver function test abnormal13.03.04.030---
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