Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ethacrynic acid
Drug ID BADD_D00840
Description A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
Indications and Usage For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.
Marketing Status approved; investigational
ATC Code C03CC01
DrugBank ID DB00903
KEGG ID D00313
MeSH ID D004976
PubChem ID 3278
TTD Drug ID D06TNL
NDC Product Code 17337-0401; 68180-159; 58032-1015; 65571-0016; 60760-773; 68682-011; 50228-334; 52817-367; 0054-0415; 0832-1690; 42973-169; 48581-320; 65841-175; 76055-0022; 69238-1126; 17337-0429; 25010-215; 42799-405; 42413-0059; 58032-2020
UNII M5DP350VZV
Synonyms Ethacrynic Acid | Acid, Ethacrynic | Etacrynic Acid | Acid, Etacrynic | Ethacrinic Acid | Acid, Ethacrinic | Hydromedin | Edecrin | Ethacrynate Sodium | Sodium, Ethacrynate | Ethacrynic Acid, Sodium Salt
Chemical Information
Molecular Formula C13H12Cl2O4
CAS Registry Number 58-54-8
SMILES CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neutropenia01.02.03.004---
Pain08.01.08.004--
Pancreatitis acute07.18.01.002---
Pyrexia08.05.02.003--
Rash23.03.13.001---
Seizure17.12.03.001--
Thrombocytopenia01.08.01.002---
Tinnitus04.04.01.002; 17.04.07.004--
Vertigo04.04.01.003; 17.02.12.002--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Decreased appetite08.01.09.028; 14.03.01.005--
Ill-defined disorder08.01.03.049---
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