Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Eszopiclone
Drug ID BADD_D00837
Description Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity[A179827], offering a safer alternative to other drugs used for insomnia. One major benefit of eszopiclone is that it is approved by the FDA for the long-term treatment of insomnia. This sets it apart from many other hypnotic sedatives, which are generally approved only for the relief of short-term (6-8 weeks) insomnia. Eszopiclone was initially approved by the FDA in 2004.[L6769]
Indications and Usage For the treatment of insomnia
Marketing Status Prescription; Discontinued
ATC Code N05CF04
DrugBank ID DB00402
KEGG ID D02624
MeSH ID D000069582
PubChem ID 969472
TTD Drug ID D06ZII
NDC Product Code 63402-191; 80425-0063; 0378-5270; 80425-0098; 65862-969; 43063-795; 63629-5319; 63187-970; 71335-0574; 68462-383; 71205-633; 68462-382; 68788-8077; 65862-968; 76420-024; 68180-322; 63278-1059; 80425-0115; 68180-324; 33342-300; 68788-6953; 33342-301; 61919-587; 70518-1310; 71205-581; 45865-830; 68180-323; 45865-829; 80425-0064; 71335-2002; 68788-7029; 55111-878; 50436-3384; 66022-0106; 71335-0089; 68788-7667; 63187-579; 50090-5084; 63187-843; 43353-185; 63187-817; 55111-619; 71335-0148; 80425-0066; 68462-384; 50090-3553; 0378-5272; 50090-3514; 60429-634; 50436-3383; 55700-581; 68071-2403; 61919-395; 61919-500; 66039-847; 0093-5539; 55700-610; 71335-0116; 61919-462; 60760-325; 55111-617; 71335-0005; 63187-665; 60429-633; 72789-067; 71335-0598; 68071-3376; 47335-587; 61919-119; 0378-5271; 66639-019; 45865-828; 71610-409; 55700-621; 47335-588; 72761-013; 70518-2979; 68788-7169; 63402-190; 47335-586; 43353-200; 72189-099; 65862-967; 50090-4202; 42043-320; 63402-193; 33342-299; 71335-1662; 61919-033; 80425-0062; 71205-384; 55289-014; 61919-514; 42043-321; 63285-831; 43353-097; 60760-511; 63285-832; 71335-1794; 76420-026; 71335-0512; 60760-526; 0093-5537; 11722-057; 71205-236; 76420-027; 80425-0168; 42043-322; 43353-101; 70518-3395; 0093-5538; 80425-0067; 50090-3989; 70518-0815; 80425-0065; 61919-991; 71205-513; 60429-632; 63285-830; 64330-044; 55111-629
Synonyms Eszopiclone | Lunesta | Estorra
Chemical Information
Molecular Formula C17H17ClN6O3
CAS Registry Number 138729-47-2
SMILES CN1CCN(CC1)C(=O)OC2C3=NC=CN=C3C(=O)N2C4=NC=C(C=C4)Cl
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Acne23.02.01.001--Not Available
Aggression19.05.01.0010.001009%Not Available
Agitation17.02.05.012; 19.06.02.0010.001514%
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.0030.003532%Not Available
Amenorrhoea05.05.01.002; 21.01.02.001--
Amnesia17.03.02.001; 19.20.01.0010.001009%
Anaemia01.03.02.001--
Anterograde amnesia17.03.02.005; 19.20.01.0050.001514%Not Available
Anxiety19.06.02.0020.002523%
Apathy19.04.04.002--Not Available
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Back pain15.03.04.0050.001009%
Bladder pain20.02.02.001--Not Available
Blood creatine phosphokinase increased13.04.01.0010.001009%
Blood pressure decreased13.14.03.0020.001009%Not Available
Body temperature increased13.15.01.001--Not Available
Breast engorgement18.08.02.001; 21.05.05.002--Not Available
Breast enlargement21.05.04.001--Not Available
Breast neoplasm16.10.02.001; 21.05.01.004--Not Available
Breast pain21.05.05.003--
Breath odour07.01.06.002--Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Bursitis15.04.01.001--Not Available
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