Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Estramustine phosphate sodium
Drug ID BADD_D00828
Description A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Indications and Usage For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate
Marketing Status approved; investigational
ATC Code L01XX11
DrugBank ID DB01196
KEGG ID D02398
MeSH ID D004961
PubChem ID 444000
TTD Drug ID D03SRY
NDC Product Code 0013-0132
UNII 75F375MT2N
Synonyms Estramustine | Estracyt | Estramustine Phosphate Sodium | Phosphate Sodium, Estramustine | Leo-275 | Leo 275 | Leo275 | NSC-89199 | NSC 89199 | NSC89199 | Emcyt | Estramustinphosphate | Estramustin Phosphate | Phosphate, Estramustin
Chemical Information
Molecular Formula C23H30Cl2NNa2O6P
CAS Registry Number 52205-73-9
SMILES CC12CCC3C(C1CCC2OP(=O)([O-])[O-])CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl.[Na+].[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Alopecia23.02.02.001--
Anxiety19.06.02.002--
Aspartate aminotransferase13.03.04.008---
Blood bilirubin13.03.04.015---
Blood lactate dehydrogenase13.04.02.009---
Breast enlargement21.05.04.001---
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.002---
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Congenital anomaly03.02.01.001---
Depression19.15.01.001--
Dermatitis23.03.04.002---
Developmental delay08.01.03.037; 19.07.05.003---
Diarrhoea07.02.01.001--
Dry skin23.03.03.001--
Dysphonia17.02.08.004; 19.19.03.002; 22.12.03.006--
Dyspnoea02.11.05.003; 22.02.01.004--
Eye pain06.08.03.002--
Flatulence07.01.04.002--
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009---
Headache17.14.01.001--
Hypercalcaemia05.04.01.002; 14.04.01.003--
Increased tendency to bruise01.01.03.005; 23.06.01.009; 24.07.06.012---
Insomnia17.15.03.002; 19.02.01.002--
Lacrimation increased06.08.02.004--
Lethargy08.01.01.008; 17.02.04.003; 19.04.04.004--
Leukopenia01.02.02.001---
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