| Pharmaceutical Information |
| Drug Name |
Escitalopram oxalate |
| Drug ID |
BADD_D00810 |
| Description |
Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram].[A185420] It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with some evidence suggesting that the R-enantiomer of racemic citalopram actively dampens the activity of escitalopram rather than existing simply as an inactive enantiomer.[A39738,A185819] Amongst SSRIs, escitalopram exerts the highest degree of selectivity for the serotonin transporter (SERT) relative to other off-targets which may explain its lower rates of adverse effects as compared to other agents in this class.[A185726] Escitalopram also differentiates itself from other SSRIs via allosteric action on its target - this may be the mechanism responsible for its observed superior efficacy and faster onset compared to other SSRIs.[A185825,A185726,A185822] |
| Indications and Usage |
Escitalopram is indicated for both acute and maintenance treatment of major depressive disorder (MDD) and for the acute treatment of generalized anxiety disorder (GAD).[L8513] It is additionally indicated for symptomatic relief of obsessive-compulsive disorder (OCD) in Canada.[L8516] |
| Marketing Status |
approved |
| ATC Code |
N06AB10 |
| DrugBank ID |
DB01175
|
| KEGG ID |
D02567
|
| MeSH ID |
D000089983
|
| PubChem ID |
146571
|
| TTD Drug ID |
D08RBC
|
| NDC Product Code |
82009-036; 58032-0134; 65015-886; 50090-6025; 65862-248; 65862-373; 68071-3265; 68084-618; 70934-060; 71205-792; 0615-8475; 68788-8371; 0904-6427; 68554-0136; 16571-769; 42708-077; 45865-996; 55700-993; 65162-019; 70518-1291; 68001-195; 68001-196; 0615-8477; 82009-037; 0456-2021; 55111-944; 71052-647; 50090-6496; 55154-6893; 63629-2981; 63629-8042; 70518-0791; 82009-035; 45562-1130; 68554-0007; 13668-135; 43063-761; 50090-6023; 65162-021; 71205-193; 71335-9687; 0615-8476; 82982-065; 53104-7565; 70966-0032; 72761-009; 51655-147; 65862-375; 68084-617; 0456-2006; 65372-1116; 65691-0066; 13668-136; 31722-569; 55154-7288; 72789-311; 51686-0011; 64220-109; 65862-411; 50090-1279; 51672-1348; 61919-139; 65862-374; 68001-197; 71205-168; 71335-0685; 0904-6426; 0456-2011; 13668-137; 65162-020; 71205-313; 71335-0658; 65372-1143 |
| UNII |
5U85DBW7LO
|
| Synonyms |
Escitalopram | Escitalopram Oxalate | Lexapro |
|
| Chemical Information |
| Molecular Formula |
C22H23FN2O5 |
| CAS Registry Number |
219861-08-2 |
| SMILES |
CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O |
| Chemical Structure |
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| ADRs Induced by Drug |
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