Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Escitalopram
Drug ID BADD_D00809
Description Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram].[A185420] It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with some evidence suggesting that the R-enantiomer of racemic citalopram actively dampens the activity of escitalopram rather than existing simply as an inactive enantiomer.[A39738,A185819] Amongst SSRIs, escitalopram exerts the highest degree of selectivity for the serotonin transporter (SERT) relative to other off-targets which may explain its lower rates of adverse effects as compared to other agents in this class.[A185726] Escitalopram also differentiates itself from other SSRIs via allosteric action on its target - this may be the mechanism responsible for its observed superior efficacy and faster onset compared to other SSRIs.[A185825,A185726,A185822]
Indications and Usage Escitalopram is indicated for both acute and maintenance treatment of major depressive disorder (MDD) and for the acute treatment of generalized anxiety disorder (GAD).[L8513] It is additionally indicated for symptomatic relief of obsessive-compulsive disorder (OCD) in Canada.[L8516]
Marketing Status approved
ATC Code N06AB10
DrugBank ID DB01175
KEGG ID D07913
MeSH ID D000089983
PubChem ID 146570
TTD Drug ID D08RBC
NDC Product Code 80425-0320; 50090-4915; 51655-284; 53002-1431; 67296-1200; 0456-2010; 0456-2020; 69097-848; 70518-1785; 71335-1030; 0615-8366; 42708-163; 45865-699; 55700-847; 69844-079; 72189-424; 72189-451; 16729-168; 43547-281; 43547-282; 61919-652; 63187-281; 68001-456; 68071-5248; 68788-7461; 69844-077; 70934-630; 68001-454; 68071-2035; 68645-520; 68788-7510; 69844-078; 70934-957; 71205-344; 71610-425; 71610-534; 72189-449; 16571-755; 16729-170; 50090-2196; 51655-236; 53002-2438; 60760-393; 68788-7912; 70518-2317; 70771-1145; 71335-1002; 71335-1187; 71335-1307; 16571-757; 51655-766; 54838-551; 70518-2430; 70771-1147; 50090-4363; 50090-5312; 50090-6534; 51655-116; 51655-149; 69097-847; 69097-849; 70518-1876; 71205-325; 76282-250; 76282-251; 42708-155; 50090-1930; 70518-2472; 70518-3151; 70771-1146; 82982-030; 43547-280; 50090-6190; 51655-277; 55700-818; 63187-217; 67296-1597; 68001-455; 68645-519; 0456-2005; 70518-1805; 70518-2597; 71335-1571; 72189-438; 0615-8365; 72789-194; 76282-249; 16571-756; 33342-053; 60760-170; 65162-705; 71205-782; 71335-1241; 71335-2058; 0615-8348; 16729-169; 43063-661
UNII 4O4S742ANY
Synonyms Escitalopram | Escitalopram Oxalate | Lexapro
Chemical Information
Molecular Formula C20H21FN2O
CAS Registry Number 128196-01-0
SMILES CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Infection parasitic11.01.08.003---
Influenza11.05.03.001; 22.07.02.001---
Influenza like illness08.01.03.0100.000144%
Ingrowing nail23.02.05.011---
Inguinal hernia07.16.02.0010.000019%-
Initial insomnia17.15.03.005; 19.02.01.0050.000051%-
Injection site bruising08.02.03.042; 12.07.03.042; 23.03.11.015; 24.07.06.0170.000074%-
Injection site erythema08.02.03.001; 12.07.03.001; 23.03.06.0150.000106%-
Injection site induration08.02.03.007; 12.07.03.0070.000235%-
Injection site mass08.02.03.009; 12.07.03.0100.000286%-
Injection site pain08.02.03.010; 12.07.03.0110.000383%-
Injection site pruritus08.02.03.013; 12.07.03.014; 23.03.12.0070.000074%-
Injection site reaction08.02.03.014; 12.07.03.0150.000415%
Injection site warmth08.02.03.036; 12.07.03.0360.000074%-
Injury12.01.08.004---
Insomnia17.15.03.002; 19.02.01.0020.001563%
Intentional self-injury12.01.08.036; 19.12.01.0020.000626%-
International normalised ratio increased13.01.02.008--
Interstitial lung disease10.02.01.033; 22.01.02.003---
Intracranial pressure increased17.07.02.0020.000038%-
Intraventricular haemorrhage17.08.01.017; 24.07.04.0080.000028%-
Iritis06.04.03.002; 10.02.01.022---
Iron deficiency anaemia01.03.01.002; 14.13.02.0010.000019%-
Irritability08.01.03.011; 19.04.02.0130.000853%
Irritable bowel syndrome07.02.04.003; 19.24.01.003---
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.0300.000142%-
Jaundice neonatal01.06.04.006; 09.01.01.008; 18.04.08.0010.000019%-
Joint dislocation12.04.02.007; 15.01.07.002---
Joint stiffness15.01.02.003---
Judgement impaired17.03.03.005; 19.05.01.0090.000038%-
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ADReCS-Target
Drug Name ADR Term Target
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