Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ertapenem
Drug ID BADD_D00802
Description Ertapenem is a carbapenem antibiotic drug that is marketed under the trade name Invanz by Merck & Co. pharmaceutical company. It is structurally similar to [meropenem] and possesses a 1-beta-methyl group.
Indications and Usage For the treatment the following moderate to severe infections caused by susceptible isolates of the designated microorganisms: (1) complicated intra-abdominal infections due to Escherichia coli, Clostridium clostridioforme, Eubacterium lentum, Peptostreptococcus species, Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, or Bacteroides uniformis, (2) complicated skin and skin structure infections, including diabetic foot infections without osteomyelitis due to Staphylococcus aureus (methicillin susceptible isolates only), Streptococcus agalactiae, Streptococcus pyogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Bacteroides fragilis, Peptostreptococcus species, Porphyromonas asaccharolytica, or Prevotella bivia, (3) community acquired pneumonia due to Streptococcus pneumoniae (penicillin susceptible isolates only) including cases with concurrent bacteremia, Haemophilus influenzae (beta-lactamase negative isolates only), or Moraxella catarrhalis, (4) complicated urinary tract infections including pyelonephritis due to Escherichia coli, including cases with concurrent bacteremia, or Klebsiella pneumoniae, (5) acute pelvic infections including postpartum endomyometritis, septic abortion and post surgical gynecologic infections due to Streptococcus agalactiae, Escherichia coli, Bacteroides fragilis, Porphyromonas asaccharolytica, Peptostreptococcus species, or Prevotella bivia.
Marketing Status approved; investigational
ATC Code J01DH03
DrugBank ID DB00303
KEGG ID D07908
MeSH ID D000077727
PubChem ID 150610
TTD Drug ID D0Q1MS
NDC Product Code 43598-901; 55150-282; 0409-3510; 16714-889; 44567-820
UNII G32F6EID2H
Synonyms Ertapenem | Invanoz | Invanz | Ertapenem Sodium
Chemical Information
Molecular Formula C22H25N3O7S
CAS Registry Number 153832-46-3
SMILES CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)NC4=CC=CC(=C4)C(=O)O)C(=O)O)C(C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Infection11.01.08.002---
Injection site erythema08.02.03.001; 12.07.03.001; 23.03.06.015---
Injection site induration08.02.03.007; 12.07.03.007---
Injection site pain08.02.03.010; 12.07.03.011---
Insomnia17.15.03.002; 19.02.01.002--
Intermittent claudication24.04.03.0010.000049%-
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Lethargy08.01.01.008; 17.02.04.003; 19.04.04.0040.000097%
Leukocytosis01.02.01.0020.000122%
Leukopenia01.02.02.0010.000267%-
Linear IgA disease10.04.02.006; 23.03.01.0150.000049%-
Lip oedema07.05.04.004; 10.01.05.004; 23.04.01.0060.000156%-
Lip swelling07.05.04.005; 10.01.05.005; 23.04.01.0070.000131%-
Liver disorder09.01.08.001---
Loss of consciousness17.02.04.0040.000243%-
Lung disorder22.02.07.0010.000073%-
Lung infiltration22.01.02.004---
Malaise08.01.01.003--
Melaena07.12.02.004; 24.07.02.013---
Memory impairment17.03.02.003; 19.20.01.0030.000131%
Menopausal symptoms21.02.02.002---
Mouth ulceration07.05.06.004---
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.0050.000073%-
Muscular weakness15.05.06.001; 17.05.03.0050.000360%
Musculoskeletal pain15.03.04.007--
Myoclonus17.02.05.0080.000365%-
Nasal congestion22.04.04.001--
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.001--
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