Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ergotamine
Drug ID BADD_D00796
Description A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
Indications and Usage For use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called "histaminic cephalalgia".
Marketing Status approved
ATC Code N02CA02
DrugBank ID DB00696
KEGG ID D07906
MeSH ID D004878
PubChem ID 8223
TTD Drug ID D01TSI
NDC Product Code Not Available
UNII PR834Q503T
Synonyms Ergotamine | Ergomar | Ergostat | Ergotamine Tartrate | Tartrate, Ergotamine | Ergotamine Tartrate (2:1) | Ergotaminine | Ergo-Kranit | Ergo Kranit | Lingraine | Cornutamine | Ergo Sanol | Ergodryl Mono | Mono, Ergodryl | Gynergen
Chemical Information
Molecular Formula C33H35N5O5
CAS Registry Number 379-79-3
SMILES CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C 6=C5)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001---
Bradycardia02.03.02.002---
Cyanosis02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.007--
Gangrene11.02.01.003; 23.06.06.001; 24.04.05.003---
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Myalgia15.05.02.001--
Nausea07.01.07.001--
Pain08.01.08.004--
Paraesthesia17.02.06.005; 23.03.03.094--
Peripheral coldness08.01.09.010; 23.06.04.008; 24.04.03.006---
Pruritus23.03.12.001--
Pulse absent13.14.04.005---
Sensory loss17.02.07.007---
Tachycardia02.03.02.007---
Vertigo04.04.01.003; 17.02.12.002--
Vomiting07.01.07.003--
Localised oedema02.05.04.006; 08.01.07.011; 14.05.06.009--
Emotional distress19.04.02.008---
Musculoskeletal discomfort15.03.04.001---
Ischaemia24.04.02.004---
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