Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epirubicin hydrochloride
Drug ID BADD_D00785
Description An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Indications and Usage For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.
Marketing Status Prescription; Discontinued
ATC Code L01DB03
DrugBank ID DB00445
KEGG ID D02214
MeSH ID D015251
PubChem ID 65348
TTD Drug ID D0C9XJ
NDC Product Code 77391-002; 0009-5093; 0143-9202; 0009-5091; 59923-701; 0143-9203; 27831-002
Synonyms Epirubicin | 4'-Epidoxorubicin | 4' Epidoxorubicin | 4'-Epi-Doxorubicin | 4' Epi Doxorubicin | 4'-Epi-Adriamycin | 4' Epi Adriamycin | 4'-Epiadriamycin | 4' Epiadriamycin | 4'-Epi-DXR | 4' Epi DXR | EPI-cell | EPI cell | EPIcell | Epilem | Farmorubicina | IMI-28 | IMI 28 | IMI28 | NSC-256942 | NSC 256942 | NSC256942 | Ellence | Pharmorubicin | Farmorubicine | Farmorubicin | Epirubicin Hydrochloride | Hydrochloride, Epirubicin
Chemical Information
Molecular Formula C27H29NO11.ClH
CAS Registry Number 25316-40-9
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O .Cl
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Leukaemia01.10.03.001; 16.01.03.001--
Leukopenia01.02.02.001--Not Available
Loss of consciousness17.02.04.004--Not Available
Lymphopenia01.02.02.002--Not Available
Malaise08.01.01.003--
Metastases to liver09.04.02.004; 16.22.02.001--Not Available
Mouth ulceration07.05.06.004--Not Available
Mucosal inflammation08.01.06.002--Not Available
Mucous membrane disorder08.01.06.004--Not Available
Muscle spasms15.05.03.004--
Muscular weakness15.05.06.001; 17.05.03.005--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Myelodysplastic syndrome01.10.04.001; 16.01.04.001--
Nail disorder23.02.05.002--
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neuralgia17.02.07.005--
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Oedema08.01.07.006; 14.05.06.010--Not Available
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Oesophagitis07.08.05.001--
Opportunistic infection11.01.08.007--Not Available
Oral candidiasis07.05.07.001; 11.03.03.004--Not Available
Oral pain07.05.03.002--
Orthostatic hypotension17.05.01.020; 24.06.03.004--Not Available
Ovarian cancer16.12.04.001; 21.11.01.003--Not Available
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