| Pharmaceutical Information |
| Drug Name |
Duloxetine |
| Drug ID |
BADD_D00734 |
| Description |
Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686.[A178741] Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder.[L6454] It has since received approval for a variety of indications including the treatment of neuropathic pain, Generalized Anxiety disorder, osteoarthritis, and stress incontinence. Duloxetine continues to be investigated for the treatment of pain in cancer, surgery, and more. |
| Indications and Usage |
**Indicated** for:
1) Management of Major Depressive Disorder.[label]
2) Management of Generalized Anxiety Disorder.[label]
3) Management of diabetic peripheral neuropathy.[label]
4) Management of fibromyalgia.[label]
5) Management of chronic musculoskeletal pain.[label]
6) Management of osteoarthritis of the knee in adults.[L6364]
7) Management of chronic lower back pain in adults.[L6364]
8) Management of stress urinary incontinence in adult women.[L6367]
**Off-label** uses include:
1) Management of chemotherapy-induced peripheral neuropathy.[A178603]
2) Management of stress urinary incontinence in adult men after prostatectomy until recovery is complete.[L6370] |
| Marketing Status |
approved |
| ATC Code |
N06AX21 |
| DrugBank ID |
DB00476
|
| KEGG ID |
D07880
|
| MeSH ID |
D000068736
|
| PubChem ID |
60835
|
| TTD Drug ID |
D01AXB
|
| NDC Product Code |
49252-007; 50268-269; 50268-270; 51655-237; 55700-605; 61919-422; 63629-5174; 65841-799; 71205-358; 71205-445; 71205-525; 71205-602; 31722-582; 47335-616; 47335-617; 50268-286; 0228-2892; 60760-559; 70518-1054; 71205-005; 71610-403; 27241-098; 31722-170; 43547-380; 43547-381; 47335-382; 47335-619; 55700-628; 60760-462; 61919-483; 67877-264; 68084-692; 68180-295; 68180-296; 55700-727; 63629-5202; 70518-2630; 76420-236; 31722-169; 47335-383; 47335-618; 49252-009; 50090-6406; 55154-4981; 63629-8051; 63629-8748; 68180-294; 68180-297; 70518-1128; 70518-1139; 70518-3287; 70710-1538; 27241-164; 50268-287; 53002-1494; 60760-461; 65841-801; 67877-265; 70518-2855; 71335-1672; 71335-1964; 46708-278; 68071-2709; 68084-683; 68382-387; 70518-3601; 71335-0402; 71335-2017; 27241-097; 27241-099; 31722-168; 49252-008; 0228-2891; 53002-1561; 68788-7672; 70710-1539; 70771-1344; 70771-1346; 80425-0311; 65977-0035; 46708-280; 47335-381; 50090-6040; 65841-800; 68382-385; 68788-7935; 70710-1537; 70771-1345; 80425-0119; 31722-581; 46708-279; 50090-6281; 50268-288; 55154-4980; 67877-263; 68084-675; 68382-386; 70518-1011; 70518-3177; 31722-583; 43547-379; 45865-813; 50090-4708; 50090-5940; 50268-271; 0228-2890 |
| UNII |
O5TNM5N07U
|
| Synonyms |
Duloxetine Hydrochloride | Hydrochloride, Duloxetine | Duloxetine HCl | HCl, Duloxetine | LY 248686 | LY-248686 | LY248686 | Duloxetine Ethanedioate (1:1), (+-)-isomer - T353987 | LY 227942 | LY-227942 | LY227942 | Duloxetine | N-methyl-3-(1-naphthalenyloxy)-3-(2-thiophene)propanamide | N-methyl-3-(1-naphthalenyloxy)-2-thiophenepropanamine | Duloxetine, (+)-isomer | Cymbalta |
|
| Chemical Information |
| Molecular Formula |
C18H19NOS |
| CAS Registry Number |
116539-59-4 |
| SMILES |
CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32 |
| Chemical Structure |
|
|
| ADRs Induced by Drug |
|
|
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
|
|
|
