| Pharmaceutical Information |
| Drug Name |
Doxorubicin |
| Drug ID |
BADD_D00723 |
| Description |
Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix. |
| Indications and Usage |
Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer. |
| Marketing Status |
approved; investigational |
| ATC Code |
L01DB01 |
| DrugBank ID |
DB00997
|
| KEGG ID |
D03899
|
| MeSH ID |
D004317
|
| PubChem ID |
31703
|
| TTD Drug ID |
D07VLY
|
| NDC Product Code |
12543-3209; 70121-1218 |
| UNII |
80168379AG
|
| Synonyms |
Doxorubicin | Farmiblastina | Ribodoxo | Rubex | Adriamycin | Adriblastin | Adriblastine | Adriblastina | Adriablastine | Adriablastin | Adrimedac | DOXO-cell | DOXO cell | Urokit Doxo-cell | Urokit Doxo cell | Doxolem | Doxorubicin Hexal | Doxorubicin Hydrochloride | Hydrochloride, Doxorubicin | Doxorubicin NC | Doxorubicina Ferrer Farm | Doxorubicina Funk | Doxorubicina Tedec | Doxorubicine Baxter | Doxotec | Myocet | Onkodox |
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| Chemical Information |
| Molecular Formula |
C27H29NO11 |
| CAS Registry Number |
23214-92-8 |
| SMILES |
CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O |
| Chemical Structure |
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| ADRs Induced by Drug |
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