Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Doxercalciferol
Drug ID BADD_D00722
Description Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, as well as for the treatment of secondary hyperparathyroidism in patients with Stage 3 or Stage 4 chronic kidney disease. Doxercalciferol is marketed under the brand name Hectoral by Genzyme Corporation, and is manufactured by Catalent Pharma Solutions, Inc.
Indications and Usage Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, as well as for the treatment of secondary hyperparathyroidism in patients with Stage 3 or Stage 4 chronic kidney disease.
Marketing Status approved
ATC Code H05BX03
DrugBank ID DB06410
KEGG ID D01009
MeSH ID C042533
PubChem ID 5281107
TTD Drug ID D0G5CF
NDC Product Code 11014-0030; 14474-023; 63415-0040; 62135-452; 64980-229; 70121-1393; 11014-0028; 58468-0127; 64980-228; 11014-0029; 71288-802; 55150-358; 62135-451; 64980-230; 54239-010; 43598-850; 58468-0123; 70121-1392; 62332-690; 68180-718; 66499-0011; 23155-540; 0409-1330; 0641-6154; 55150-359; 23155-538; 23155-539; 55150-357; 62135-450; 70121-1408
UNII 3DIZ9LF5Y9
Synonyms 1 alpha-hydroxyergocalciferol | 1alpha-hydroxyvitamin D2 | doxacalciferol | doxercalciferol | 1alpha(OH)2D2 | 1alpha-OHD2 | Hectorol
Chemical Information
Molecular Formula C28H44O2
CAS Registry Number 54573-75-0
SMILES CC(C)C(C)C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Photophobia06.01.01.004; 17.17.02.006--
Polydipsia05.03.03.002; 14.05.02.001---
Polyuria20.02.03.002---
Pruritus23.03.12.0010.337693%
Rash23.03.13.0010.117389%-
Rash erythematous23.03.13.0290.018225%-
Rash pruritic23.03.13.0300.027337%-
Rhinitis11.01.13.004; 22.07.03.006--
Rhinorrhoea22.12.03.021--
Seizure17.12.03.0010.005360%
Sensory disturbance17.02.07.006---
Sleep disorder19.02.04.001---
Somnolence17.02.04.006; 19.02.05.003--
Swelling08.01.03.0150.005360%-
Tachycardia02.03.02.0070.005360%-
Throat irritation07.05.05.037; 22.12.03.0290.027337%-
Throat tightness19.01.02.005; 22.12.03.0310.005360%-
Unresponsive to stimuli17.02.05.0310.016081%-
Urinary tract infection11.01.14.004; 20.08.02.001--
Urticaria10.01.06.001; 23.04.02.0010.057354%
Vomiting07.01.07.0030.080939%
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Mental status changes19.07.01.0010.011792%-
Musculoskeletal discomfort15.03.04.001---
Growth retardation05.03.02.007; 14.03.02.031; 15.03.05.016--
Disturbance in sexual arousal19.08.04.003---
Urine output increased13.13.03.002---
Hot flush08.01.03.027; 21.02.02.001; 24.03.01.0050.041810%
Poisoning12.03.01.004---
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ADReCS-Target
Drug Name ADR Term Target
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